Solar elastosis in cutaneous melanoma.


Journal Article

By studying more than 1,200 patients with cutaneous melanoma and long-term follow-up, I examined the relationship between solar elastosis and age at diagnosis of melanoma, key features of melanoma, and the outcome of overall survival in melanoma. I found that melanomas with elastosis were diagnosed significantly later than those without elastosis (P approximately 0; log-rank test). This result may be because elastosis is positively related to age. However, I also found that melanomas of head and neck areas, which tend to have more elastosis, were diagnosed at later ages than melanomas of other body sites (P = 1.2 x 10-5; log-rank test). Thus, a second explanation for the results favors a protective effect of elastosis on the development of cutaneous melanoma, possibly related to increased levels of vitamin D. I also found that once melanoma develops, cases with elastosis demonstrated no differences in thickness, mitotic rate, ulceration, or overall survival time from cases without elastosis.

Full Text

Duke Authors

Cited Authors

  • Vollmer, RT

Published Date

  • August 2007

Published In

Volume / Issue

  • 128 / 2

Start / End Page

  • 260 - 264

PubMed ID

  • 17638660

Pubmed Central ID

  • 17638660

International Standard Serial Number (ISSN)

  • 0002-9173

Digital Object Identifier (DOI)

  • 10.1309/7MHX96XH3DTY32TQ


  • eng

Conference Location

  • England