Factors influencing phenotypic diversity of human prostate carcinoma cells metastasizing in athymic nude mice.


Journal Article

Three related human prostate carcinoma cell lines, PC-3, 1-LN-PC-3-1A (1-LN), and 1-LN-PC-3-1A clone 4 (clone 4) were compared in terms of relative metastatic capacity in adult and young male nude mice. Only 1-LN produced lung metastases after intravenous injection into both 6- to 8-week-old and 4-week-old nude mice, as well as in mice injected intraperitoneally. The extent of the phenotypic diversity exhibited by these human prostate tumor lines was influenced by inherent dissemination ability, age of the host, and route of injection. These lines provide a useful system for the analysis of the biology of human tumor metastasis in nude mice.

Full Text

Duke Authors

Cited Authors

  • Ware, JL; Lieberman, AP; Webb, KS; Vollmer, RT

Published Date

  • 1985

Published In

Volume / Issue

  • 53 / 3

Start / End Page

  • 163 - 169

PubMed ID

  • 4007233

Pubmed Central ID

  • 4007233

International Standard Serial Number (ISSN)

  • 0304-3568

Digital Object Identifier (DOI)

  • 10.1159/000163308


  • eng

Conference Location

  • Switzerland