Systemic kappa light-chain deposition. An ultrastructural and immunohistochemical study.


Journal Article

This report describes the pathology of kappa light-chain deposition in a 55-year-old patient who presented with respiratory insufficiency and hepatomegaly. Biopsies of lung and liver showed PAS-positive deposits which did not stain with congo red, crystal violet, or thioflavin-T. By indirect immunoperoxidase techniques, the deposits were composed of kappa light-chain immunoglobin. Electron microscopy revealed granular and fibrillar electron-dense material which lacked the characteristics of amyloid. Subsequent clinical studies showed this patient had a plasma cell dyscrasia. These data show that kappa light-chain deposition is not limited to the kidney, and that the first manifestation of a plasma cell dyscrasia may be systemic deposits of light chain. These deposits can be distinguished from amyloid by their immunochemical, tinctorial, and ultrastructural appearance.

Full Text

Duke Authors

Cited Authors

  • Linder, J; Croker, BP; Vollmer, RT; Shelburne, J

Published Date

  • January 1, 1983

Published In

Volume / Issue

  • 7 / 1

Start / End Page

  • 85 - 93

PubMed ID

  • 6402947

Pubmed Central ID

  • 6402947

International Standard Serial Number (ISSN)

  • 0147-5185

Digital Object Identifier (DOI)

  • 10.1097/00000478-198301000-00009


  • eng

Conference Location

  • United States