Prognostic value of cytologic examination of peritoneal washings in patients with endometrial carcinoma.

Published

Journal Article

Peritoneal pelvic washings from 54 women with pathologic stage I endometrial carcinoma were evaluated in a blind retrospective fashion for the concentration of malignant cells present. None of the 42 patients with normal washings developed recurrence after a median disease-free survival of 36 months. Of the 12 patients with adenocarcinoma in the washings, 4 had high concentrations of malignant cells (greater than 1000 cells/100 ml sample), and all 4 died as a consequence of carcinoma within two years. The remaining eight patients had lower concentrations of malignant cells in the washings (less than 1000 cells/100 ml sample), and six of these patients had no evidence of disease after 37 to 64 months. Cox's nonparametric statistical model showed that increasing concentrations of adenocarcinoma cells in washings significantly shortened the time to recurrence of disease. The abundance of malignant cells has prognostic importance in identifying those patients with pathologic stage I disease who may require more aggressive therapy.

Full Text

Duke Authors

Cited Authors

  • Szpak, CA; Creasman, WT; Vollmer, RT; Johnston, WW

Published Date

  • November 1, 1981

Published In

Volume / Issue

  • 25 / 6

Start / End Page

  • 640 - 646

PubMed ID

  • 6171978

Pubmed Central ID

  • 6171978

International Standard Serial Number (ISSN)

  • 0001-5547

Language

  • eng

Conference Location

  • Switzerland