The pharmacogenetics of coumarin therapy.

Journal Article (Journal Article;Review)

Vitamin K antagonists (coumarins) are widely-used oral anticoagulants for the prevention of venous thromboembolism and strokes. Wide inter-individual variation in dose response and frequent bleeds characterize the initiation of coumarin therapy. Over the past 10 years both genetic and nongenetic determinants of coumarin dose response have been identified. A comprehensive pharmacogenetics approach to warfarin therapy has the potential to improve the safety and efficiency of warfarin initiation.

Full Text

Duke Authors

Cited Authors

  • Voora, D; McLeod, HL; Eby, C; Gage, BF

Published Date

  • July 2005

Published In

Volume / Issue

  • 6 / 5

Start / End Page

  • 503 - 513

PubMed ID

  • 16014000

International Standard Serial Number (ISSN)

  • 1462-2416

Digital Object Identifier (DOI)

  • 10.2217/14622416.6.5.503


  • eng

Conference Location

  • England