The pharmacogenetics of coumarin therapy.
Journal Article (Journal Article;Review)
Vitamin K antagonists (coumarins) are widely-used oral anticoagulants for the prevention of venous thromboembolism and strokes. Wide inter-individual variation in dose response and frequent bleeds characterize the initiation of coumarin therapy. Over the past 10 years both genetic and nongenetic determinants of coumarin dose response have been identified. A comprehensive pharmacogenetics approach to warfarin therapy has the potential to improve the safety and efficiency of warfarin initiation.
Full Text
Duke Authors
Cited Authors
- Voora, D; McLeod, HL; Eby, C; Gage, BF
Published Date
- July 2005
Published In
Volume / Issue
- 6 / 5
Start / End Page
- 503 - 513
PubMed ID
- 16014000
International Standard Serial Number (ISSN)
- 1462-2416
Digital Object Identifier (DOI)
- 10.2217/14622416.6.5.503
Language
- eng
Conference Location
- England