Suppression of cortical epileptiform activity by generalized and localized ECoG desynchronization.

Journal Article (Journal Article)

The effects of high frequency electrical stimulation of both diffusely projecting brain regions and regions of more restricted projection were studied on penicillin-induced cortical epileptiform focal activity in the cat. Results obtained were contingent on the level of focal activity present at the time of stimulation. Very active foci (spike rates above 0.5/sec) were uniformly driven by stimulation of all structures under study. Foci exhibiting weak to moderate levels of activity were, on the other hand, inhibited both during and following stimulation. Episodes of spike suppression induced through stimulation of diffusely projecting structures were typically followed by an intensified "rebound" of interictal activity. Episodes of suppression induced through stimulation of regions of limited projection were not followed by such rebounds, an effect most dramatically apparent with caudate stimulation and motor cortex foci. Results are discussed in terms of the interaction between naturally occurring brain rhythms in sleep and arousal with the epileptic process.

Full Text

Duke Authors

Cited Authors

  • Wagner, R; Feeney, DM; Gullotta, FP; Cote, IL

Published Date

  • November 1, 1975

Published In

Volume / Issue

  • 39 / 5

Start / End Page

  • 499 - 506

PubMed ID

  • 52443

International Standard Serial Number (ISSN)

  • 0013-4694

Digital Object Identifier (DOI)

  • 10.1016/0013-4694(75)90051-6


  • eng

Conference Location

  • Ireland