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Suppression of cortical epileptiform activity by generalized and localized ECoG desynchronization.

Publication ,  Journal Article
Wagner, R; Feeney, DM; Gullotta, FP; Cote, IL
Published in: Electroencephalogr Clin Neurophysiol
November 1975

The effects of high frequency electrical stimulation of both diffusely projecting brain regions and regions of more restricted projection were studied on penicillin-induced cortical epileptiform focal activity in the cat. Results obtained were contingent on the level of focal activity present at the time of stimulation. Very active foci (spike rates above 0.5/sec) were uniformly driven by stimulation of all structures under study. Foci exhibiting weak to moderate levels of activity were, on the other hand, inhibited both during and following stimulation. Episodes of spike suppression induced through stimulation of diffusely projecting structures were typically followed by an intensified "rebound" of interictal activity. Episodes of suppression induced through stimulation of regions of limited projection were not followed by such rebounds, an effect most dramatically apparent with caudate stimulation and motor cortex foci. Results are discussed in terms of the interaction between naturally occurring brain rhythms in sleep and arousal with the epileptic process.

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Published In

Electroencephalogr Clin Neurophysiol

DOI

ISSN

0013-4694

Publication Date

November 1975

Volume

39

Issue

5

Start / End Page

499 / 506

Location

Ireland

Related Subject Headings

  • Time Factors
  • Thalamic Nuclei
  • Seizures
  • Penicillin G
  • Neural Inhibition
  • Male
  • Female
  • Electroencephalography
  • Electric Stimulation Therapy
  • Electric Stimulation
 

Citation

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Wagner, R., Feeney, D. M., Gullotta, F. P., & Cote, I. L. (1975). Suppression of cortical epileptiform activity by generalized and localized ECoG desynchronization. Electroencephalogr Clin Neurophysiol, 39(5), 499–506. https://doi.org/10.1016/0013-4694(75)90051-6
Wagner, R., D. M. Feeney, F. P. Gullotta, and I. L. Cote. “Suppression of cortical epileptiform activity by generalized and localized ECoG desynchronization.Electroencephalogr Clin Neurophysiol 39, no. 5 (November 1975): 499–506. https://doi.org/10.1016/0013-4694(75)90051-6.
Wagner R, Feeney DM, Gullotta FP, Cote IL. Suppression of cortical epileptiform activity by generalized and localized ECoG desynchronization. Electroencephalogr Clin Neurophysiol. 1975 Nov;39(5):499–506.
Wagner, R., et al. “Suppression of cortical epileptiform activity by generalized and localized ECoG desynchronization.Electroencephalogr Clin Neurophysiol, vol. 39, no. 5, Nov. 1975, pp. 499–506. Pubmed, doi:10.1016/0013-4694(75)90051-6.
Wagner R, Feeney DM, Gullotta FP, Cote IL. Suppression of cortical epileptiform activity by generalized and localized ECoG desynchronization. Electroencephalogr Clin Neurophysiol. 1975 Nov;39(5):499–506.

Published In

Electroencephalogr Clin Neurophysiol

DOI

ISSN

0013-4694

Publication Date

November 1975

Volume

39

Issue

5

Start / End Page

499 / 506

Location

Ireland

Related Subject Headings

  • Time Factors
  • Thalamic Nuclei
  • Seizures
  • Penicillin G
  • Neural Inhibition
  • Male
  • Female
  • Electroencephalography
  • Electric Stimulation Therapy
  • Electric Stimulation