Genomic signatures of diet-related shifts during human origins.

Journal Article (Review;Journal Article)

There are numerous anthropological analyses concerning the importance of diet during human evolution. Diet is thought to have had a profound influence on the human phenotype, and dietary differences have been hypothesized to contribute to the dramatic morphological changes seen in modern humans as compared with non-human primates. Here, we attempt to integrate the results of new genomic studies within this well-developed anthropological context. We then review the current evidence for adaptation related to diet, both at the level of sequence changes and gene expression. Finally, we propose some ways in which new technologies can help identify specific genomic adaptations that have resulted in metabolic and morphological differences between humans and non-human primates.

Full Text

Duke Authors

Cited Authors

  • Babbitt, CC; Warner, LR; Fedrigo, O; Wall, CE; Wray, GA

Published Date

  • April 2011

Published In

Volume / Issue

  • 278 / 1708

Start / End Page

  • 961 - 969

PubMed ID

  • 21177690

Pubmed Central ID

  • PMC3049039

Electronic International Standard Serial Number (EISSN)

  • 1471-2954

International Standard Serial Number (ISSN)

  • 0962-8452

Digital Object Identifier (DOI)

  • 10.1098/rspb.2010.2433


  • eng