A dichotomy of protection by bcl-2 from mitochondrial poisons

Journal Article (Journal Article)

Bcl-2 is a primarily mitochondrial protein that represses programmed cell death. We find that cells overexpressing Bcl-2 are protected from death induced by treatment agents that induce Reactive Oxygen Species, such as 95% oxygen, H2O2, tBOOH, BSO, doxorubicin and xanthine + xanthine oxidase. However Bcl-2 did not protect cells treated with the respiratory chain inhibitors MPP+, rotenone, 3-NPA, antimycin A and cyanide. Thus while oxidants trigger programmed cell death, acute poisons of the electron transport chain kill cells by a Bcl-2 independent mechanism.

Duke Authors

Cited Authors

  • Hutching, TP; Wang, E; Bredesen, D; Cortopassil, GA

Published Date

  • January 1, 1996

Published In

Volume / Issue

  • 24 / 4

International Standard Serial Number (ISSN)

  • 0300-5127

Citation Source

  • Scopus