Axonally translated SMADs link up BDNF and retrograde BMP signaling.

Journal Article (Journal Article)

Axonal target-derived BMP and neurotrophin signaling are both known to regulate neuronal gene expression, differentiation, and axon growth. In this issue of Neuron, Ji and Jaffrey (2012) discovered that BMP-signaling endosomes depend on BDNF-induced axonal synthesis of SMADs to retrogradely regulate transcription in developing trigeminal neurons, providing a mechanism of integrating the two target-derived signals.

Full Text

Duke Authors

Cited Authors

  • Takatoh, J; Wang, F

Published Date

  • April 12, 2012

Published In

Volume / Issue

  • 74 / 1

Start / End Page

  • 3 - 5

PubMed ID

  • 22500623

Pubmed Central ID

  • PMC3574870

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2012.03.012


  • eng

Conference Location

  • United States