Retrograde neural circuit specification by target-derived neurotrophins and growth factors.
Publication
, Journal Article
da Silva, S; Wang, F
Published in: Curr Opin Neurobiol
February 2011
Neural circuit assembly during development involves a series of highly regulated steps. While genetically pre-determined programs play key roles in the early steps including neurogenesis, migration, and initial growth and guidance of axons; increasing evidence indicates that as the axons reach their targets, the late steps of neuronal differentiation and connectivity formation may be influenced or even specified by target-derived signals. Here we attempt to provide a brief synthesized review on the roles of retrograde neurotrophin and growth factor signaling in regulating the final stages of neural circuit specificity such as axonal projection, dendritic patterning, neurotransmitter phenotype acquisition, and synapse formation.
Duke Scholars
Published In
Curr Opin Neurobiol
DOI
EISSN
1873-6882
Publication Date
February 2011
Volume
21
Issue
1
Start / End Page
61 / 67
Location
England
Related Subject Headings
- Signal Transduction
- Neurons
- Neurogenesis
- Neural Pathways
- Nerve Growth Factors
- Humans
- Cell Differentiation
- Animals
- 3209 Neurosciences
- 1702 Cognitive Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
da Silva, S., & Wang, F. (2011). Retrograde neural circuit specification by target-derived neurotrophins and growth factors. Curr Opin Neurobiol, 21(1), 61–67. https://doi.org/10.1016/j.conb.2010.07.007
Silva, Susana da, and Fan Wang. “Retrograde neural circuit specification by target-derived neurotrophins and growth factors.” Curr Opin Neurobiol 21, no. 1 (February 2011): 61–67. https://doi.org/10.1016/j.conb.2010.07.007.
da Silva S, Wang F. Retrograde neural circuit specification by target-derived neurotrophins and growth factors. Curr Opin Neurobiol. 2011 Feb;21(1):61–7.
da Silva, Susana, and Fan Wang. “Retrograde neural circuit specification by target-derived neurotrophins and growth factors.” Curr Opin Neurobiol, vol. 21, no. 1, Feb. 2011, pp. 61–67. Pubmed, doi:10.1016/j.conb.2010.07.007.
da Silva S, Wang F. Retrograde neural circuit specification by target-derived neurotrophins and growth factors. Curr Opin Neurobiol. 2011 Feb;21(1):61–67.
Published In
Curr Opin Neurobiol
DOI
EISSN
1873-6882
Publication Date
February 2011
Volume
21
Issue
1
Start / End Page
61 / 67
Location
England
Related Subject Headings
- Signal Transduction
- Neurons
- Neurogenesis
- Neural Pathways
- Nerve Growth Factors
- Humans
- Cell Differentiation
- Animals
- 3209 Neurosciences
- 1702 Cognitive Sciences