Retrograde neural circuit specification by target-derived neurotrophins and growth factors.

Journal Article (Journal Article;Review)

Neural circuit assembly during development involves a series of highly regulated steps. While genetically pre-determined programs play key roles in the early steps including neurogenesis, migration, and initial growth and guidance of axons; increasing evidence indicates that as the axons reach their targets, the late steps of neuronal differentiation and connectivity formation may be influenced or even specified by target-derived signals. Here we attempt to provide a brief synthesized review on the roles of retrograde neurotrophin and growth factor signaling in regulating the final stages of neural circuit specificity such as axonal projection, dendritic patterning, neurotransmitter phenotype acquisition, and synapse formation.

Full Text

Duke Authors

Cited Authors

  • da Silva, S; Wang, F

Published Date

  • February 2011

Published In

Volume / Issue

  • 21 / 1

Start / End Page

  • 61 - 67

PubMed ID

  • 20810276

Pubmed Central ID

  • PMC3008758

Electronic International Standard Serial Number (EISSN)

  • 1873-6882

Digital Object Identifier (DOI)

  • 10.1016/j.conb.2010.07.007


  • eng

Conference Location

  • England