Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond.

Journal Article (Journal Article)

PIK3C3/Vps34 plays important roles in the endocytic and autophagic pathways, both of which are essential for maintaining neuronal integrity. However, it is unclear how inactivating PIK3C3 may affect neuronal endosomal versus autophagic processes in vivo. We generated a conditional null allele of the Pik3c3 gene in mouse, and specifically deleted it in postmitotic sensory neurons. Subsequent analyses reveal several interesting and surprising findings.

Full Text

Duke Authors

Cited Authors

  • Zhou, X; Wang, F

Published Date

  • August 2010

Published In

Volume / Issue

  • 6 / 6

Start / End Page

  • 798 - 799

PubMed ID

  • 20562532

Pubmed Central ID

  • PMC3321846

Electronic International Standard Serial Number (EISSN)

  • 1554-8635

Digital Object Identifier (DOI)

  • 10.4161/auto.6.6.12511


  • eng

Conference Location

  • United States