Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond.
Published
Journal Article
PIK3C3/Vps34 plays important roles in the endocytic and autophagic pathways, both of which are essential for maintaining neuronal integrity. However, it is unclear how inactivating PIK3C3 may affect neuronal endosomal versus autophagic processes in vivo. We generated a conditional null allele of the Pik3c3 gene in mouse, and specifically deleted it in postmitotic sensory neurons. Subsequent analyses reveal several interesting and surprising findings.
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Duke Authors
Cited Authors
- Zhou, X; Wang, F
Published Date
- August 2010
Published In
Volume / Issue
- 6 / 6
Start / End Page
- 798 - 799
PubMed ID
- 20562532
Pubmed Central ID
- 20562532
Electronic International Standard Serial Number (EISSN)
- 1554-8635
Digital Object Identifier (DOI)
- 10.4161/auto.6.6.12511
Language
- eng
Conference Location
- United States