Formation of precise connections in the olfactory bulb occurs in the absence of odorant-evoked neuronal activity.

Published

Journal Article

Olfactory neurons expressing the same odorant receptor converge to a small number of glomeruli in the olfactory bulb. In turn, mitral and tufted cells receive and relay this information to higher cortical regions. In other sensory systems, correlated neuronal activity is thought to refine synaptic connections during development. We asked whether the pattern of connections between olfactory sensory axons and mitral cell dendrites is affected when odor-evoked signaling is eliminated in mice lacking functional olfactory cyclic nucleotide-gated (CNG) channels. We demonstrate that olfactory sensory axons converge normally in the CNG channel mutant background. We further show that the pruning of mitral cell dendrites, although slowed during development, is ultimately unperturbed in mutant animals. Thus, the olfactory CNG channel-and by inference correlated neural activity--is not required for generating synaptic specificity in the olfactory bulb.

Full Text

Duke Authors

Cited Authors

  • Lin, DM; Wang, F; Lowe, G; Gold, GH; Axel, R; Ngai, J; Brunet, L

Published Date

  • April 2000

Published In

Volume / Issue

  • 26 / 1

Start / End Page

  • 69 - 80

PubMed ID

  • 10798393

Pubmed Central ID

  • 10798393

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/s0896-6273(00)81139-3

Language

  • eng

Conference Location

  • United States