An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons.

Published

Journal Article

Olfactory sensory neurons expressing a given odorant receptor project to two topographically fixed glomeruli in the olfactory bulb. We have examined the contribution of different cell types in the olfactory bulb to the establishment of this topographic map. Mice with a homozygous deficiency in Tbr-1 lack most projection neurons, whereas mice with a homozygous deficiency in Dlx-1 and Dlx-2 lack most GABAergic interneurons. Mice bearing a P2-IRES-tau-lacZ allele and deficient in either Tbr-1 or Dlx-1/Dlx-2 reveal the convergence of axons to one medial and one lateral site at positions analogous to those observed in wild-type mice. These observations suggest that the establishment of a topographic map is not dependent upon cues provided by, or synapse formation with, the major neuronal cell types in the olfactory bulb.

Full Text

Duke Authors

Cited Authors

  • Bulfone, A; Wang, F; Hevner, R; Anderson, S; Cutforth, T; Chen, S; Meneses, J; Pedersen, R; Axel, R; Rubenstein, JL

Published Date

  • December 1998

Published In

Volume / Issue

  • 21 / 6

Start / End Page

  • 1273 - 1282

PubMed ID

  • 9883721

Pubmed Central ID

  • 9883721

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/s0896-6273(00)80647-9

Language

  • eng