Odorant receptors govern the formation of a precise topographic map.

Journal Article (Journal Article)

Olfactory neurons expressing a given odorant receptor project with precision to 2 of the 1800 glomeruli within the olfactory bulb to create a topographic map of odor quality. We demonstrate that deletions or nonsense mutations in the P2 odorant receptor gene cause the axons of these cells to wander rather than converge on a specific glomerulus. Receptor substitution experiments that replace the P2 gene with the coding region of the P3 gene result in the projection of P3-->P2 axons to a glomerulus touching the wild-type P3 glomerulus. These data, along with additional receptor substitutions, indicate that the odorant receptor plays an instructive role in the establishment of the topographic map.

Full Text

Duke Authors

Cited Authors

  • Wang, F; Nemes, A; Mendelsohn, M; Axel, R

Published Date

  • April 3, 1998

Published In

Volume / Issue

  • 93 / 1

Start / End Page

  • 47 - 60

PubMed ID

  • 9546391

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(00)81145-9


  • eng

Conference Location

  • United States