Odorant receptors govern the formation of a precise topographic map.
Publication
, Journal Article
Wang, F; Nemes, A; Mendelsohn, M; Axel, R
Published in: Cell
April 3, 1998
Olfactory neurons expressing a given odorant receptor project with precision to 2 of the 1800 glomeruli within the olfactory bulb to create a topographic map of odor quality. We demonstrate that deletions or nonsense mutations in the P2 odorant receptor gene cause the axons of these cells to wander rather than converge on a specific glomerulus. Receptor substitution experiments that replace the P2 gene with the coding region of the P3 gene result in the projection of P3-->P2 axons to a glomerulus touching the wild-type P3 glomerulus. These data, along with additional receptor substitutions, indicate that the odorant receptor plays an instructive role in the establishment of the topographic map.
Duke Scholars
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Published In
Cell
DOI
ISSN
0092-8674
Publication Date
April 3, 1998
Volume
93
Issue
1
Start / End Page
47 / 60
Location
United States
Related Subject Headings
- beta-Galactosidase
- Recombinant Proteins
- Receptors, Odorant
- Olfactory Receptor Neurons
- Olfactory Pathways
- Olfactory Bulb
- Odorants
- Nasal Mucosa
- Mutagenesis, Insertional
- Mice, Transgenic
Citation
APA
Chicago
ICMJE
MLA
NLM
Wang, F., Nemes, A., Mendelsohn, M., & Axel, R. (1998). Odorant receptors govern the formation of a precise topographic map. Cell, 93(1), 47–60. https://doi.org/10.1016/s0092-8674(00)81145-9
Wang, F., A. Nemes, M. Mendelsohn, and R. Axel. “Odorant receptors govern the formation of a precise topographic map.” Cell 93, no. 1 (April 3, 1998): 47–60. https://doi.org/10.1016/s0092-8674(00)81145-9.
Wang F, Nemes A, Mendelsohn M, Axel R. Odorant receptors govern the formation of a precise topographic map. Cell. 1998 Apr 3;93(1):47–60.
Wang, F., et al. “Odorant receptors govern the formation of a precise topographic map.” Cell, vol. 93, no. 1, Apr. 1998, pp. 47–60. Pubmed, doi:10.1016/s0092-8674(00)81145-9.
Wang F, Nemes A, Mendelsohn M, Axel R. Odorant receptors govern the formation of a precise topographic map. Cell. 1998 Apr 3;93(1):47–60.
Published In
Cell
DOI
ISSN
0092-8674
Publication Date
April 3, 1998
Volume
93
Issue
1
Start / End Page
47 / 60
Location
United States
Related Subject Headings
- beta-Galactosidase
- Recombinant Proteins
- Receptors, Odorant
- Olfactory Receptor Neurons
- Olfactory Pathways
- Olfactory Bulb
- Odorants
- Nasal Mucosa
- Mutagenesis, Insertional
- Mice, Transgenic