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Visual event-related potential changes at two different tasks in nondemented Parkinson's disease.

Publication ,  Journal Article
Wang, L; Kuroiwa, Y; Kamitani, T
Published in: J Neurol Sci
April 1, 1999

A visual oddball paradigm and an S1-S2 paradigm were employed to evoke event-related potentials (ERPs) in 38 nondemented Parkinson's disease (PD) patients and 24 healthy elderly subjects. Delayed N200 and reduced P300 amplitude in the whole PD sample were only found in the S1-S2 paradigm. Delayed N200 and reaction time in PD with short duration of illness were found only after the S1-S2 paradigm, which might be an early sign of cognitive changes in PD. This is the first study to apply an S1-S2 paradigm for a visual P300 test in PD and proved the value of this paradigm for detecting minor cognitive abnormalities. ERP changes were correlated with clinical features. Reduced P300 amplitude for the S1-S2 paradigm was significantly correlated with WAIS-R scores and gait disturbance. The correlation between P300 amplitude and clinical scores has rarely been discussed before. P300 latency during the oddball paradigm in PD was influenced by age at test, age at onset, and duration of illness. This may explain why P300 results in nondemented PD have varied among previous authors.

Duke Scholars

Published In

J Neurol Sci

DOI

ISSN

0022-510X

Publication Date

April 1, 1999

Volume

164

Issue

2

Start / End Page

139 / 147

Location

Netherlands

Related Subject Headings

  • Time Factors
  • Reference Values
  • Reaction Time
  • Parkinson Disease
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Humans
  • Female
  • Evoked Potentials, Visual
 

Citation

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Wang, L., Kuroiwa, Y., & Kamitani, T. (1999). Visual event-related potential changes at two different tasks in nondemented Parkinson's disease. J Neurol Sci, 164(2), 139–147. https://doi.org/10.1016/s0022-510x(99)00060-x
Wang, L., Y. Kuroiwa, and T. Kamitani. “Visual event-related potential changes at two different tasks in nondemented Parkinson's disease.J Neurol Sci 164, no. 2 (April 1, 1999): 139–47. https://doi.org/10.1016/s0022-510x(99)00060-x.
Wang L, Kuroiwa Y, Kamitani T. Visual event-related potential changes at two different tasks in nondemented Parkinson's disease. J Neurol Sci. 1999 Apr 1;164(2):139–47.
Wang, L., et al. “Visual event-related potential changes at two different tasks in nondemented Parkinson's disease.J Neurol Sci, vol. 164, no. 2, Apr. 1999, pp. 139–47. Pubmed, doi:10.1016/s0022-510x(99)00060-x.
Wang L, Kuroiwa Y, Kamitani T. Visual event-related potential changes at two different tasks in nondemented Parkinson's disease. J Neurol Sci. 1999 Apr 1;164(2):139–147.
Journal cover image

Published In

J Neurol Sci

DOI

ISSN

0022-510X

Publication Date

April 1, 1999

Volume

164

Issue

2

Start / End Page

139 / 147

Location

Netherlands

Related Subject Headings

  • Time Factors
  • Reference Values
  • Reaction Time
  • Parkinson Disease
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Humans
  • Female
  • Evoked Potentials, Visual