Signaling cross-talk between TGF-beta/BMP and other pathways.

Published

Journal Article (Review)

Transforming growth factor-beta (TGF-beta)/bone morphogenic protein (BMP) signaling is involved in the vast majority of cellular processes and is fundamentally important during the entire life of all metazoans. Deregulation of TGF-beta/BMP activity almost invariably leads to developmental defects and/or diseases, including cancer. The proper functioning of the TGF-beta/BMP pathway depends on its constitutive and extensive communication with other signaling pathways, leading to synergistic or antagonistic effects and eventually desirable biological outcomes. The nature of such signaling cross-talk is overwhelmingly complex and highly context-dependent. Here we review the different modes of cross-talk between TGF-beta/BMP and the signaling pathways of Mitogen-activated protein kinase, phosphatidylinositol-3 kinase/Akt, Wnt, Hedgehog, Notch, and the interleukin/interferon-gamma/tumor necrosis factor-alpha cytokines, with an emphasis on the underlying molecular mechanisms.

Full Text

Duke Authors

Cited Authors

  • Guo, X; Wang, X-F

Published Date

  • January 2009

Published In

Volume / Issue

  • 19 / 1

Start / End Page

  • 71 - 88

PubMed ID

  • 19002158

Pubmed Central ID

  • 19002158

Electronic International Standard Serial Number (EISSN)

  • 1748-7838

Digital Object Identifier (DOI)

  • 10.1038/cr.2008.302

Language

  • eng

Conference Location

  • England