Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.

Published

Journal Article

Molecular mechanisms associated with tumor metastasis remain poorly understood. Here we report that acquired expression of periostin by colon cancer cells greatly promoted metastatic development of colon tumors. Periostin is overexpressed in more than 80% of human colon cancers examined with highest expression in metastatic tumors. Periostin expression dramatically enhanced metastatic growth of colon cancer by both preventing stress-induced apoptosis in the cancer cells and augmenting endothelial cell survival to promote angiogenesis. At the molecular level, periostin activated the Akt/PKB signaling pathway through the alpha(v)beta(3) integrins to increase cellular survival. These data demonstrated that the survival-promoting function is crucial for periostin to promote tumor metastasis of colon cancer.

Full Text

Duke Authors

Cited Authors

  • Bao, S; Ouyang, G; Bai, X; Huang, Z; Ma, C; Liu, M; Shao, R; Anderson, RM; Rich, JN; Wang, X-F

Published Date

  • April 2004

Published In

Volume / Issue

  • 5 / 4

Start / End Page

  • 329 - 339

PubMed ID

  • 15093540

Pubmed Central ID

  • 15093540

Electronic International Standard Serial Number (EISSN)

  • 1878-3686

International Standard Serial Number (ISSN)

  • 1535-6108

Digital Object Identifier (DOI)

  • 10.1016/s1535-6108(04)00081-9

Language

  • eng