Skip to main content
Journal cover image

Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.

Publication ,  Journal Article
Bao, S; Ouyang, G; Bai, X; Huang, Z; Ma, C; Liu, M; Shao, R; Anderson, RM; Rich, JN; Wang, X-F
Published in: Cancer Cell
April 2004

Molecular mechanisms associated with tumor metastasis remain poorly understood. Here we report that acquired expression of periostin by colon cancer cells greatly promoted metastatic development of colon tumors. Periostin is overexpressed in more than 80% of human colon cancers examined with highest expression in metastatic tumors. Periostin expression dramatically enhanced metastatic growth of colon cancer by both preventing stress-induced apoptosis in the cancer cells and augmenting endothelial cell survival to promote angiogenesis. At the molecular level, periostin activated the Akt/PKB signaling pathway through the alpha(v)beta(3) integrins to increase cellular survival. These data demonstrated that the survival-promoting function is crucial for periostin to promote tumor metastasis of colon cancer.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cancer Cell

DOI

ISSN

1535-6108

Publication Date

April 2004

Volume

5

Issue

4

Start / End Page

329 / 339

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Signal Transduction
  • Proto-Oncogene Proteins c-akt
  • Proto-Oncogene Proteins
  • Protein Serine-Threonine Kinases
  • Oncology & Carcinogenesis
  • Mice, Nude
  • Mice
  • Liver Neoplasms
  • Integrin alphaVbeta3
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bao, S., Ouyang, G., Bai, X., Huang, Z., Ma, C., Liu, M., … Wang, X.-F. (2004). Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell, 5(4), 329–339. https://doi.org/10.1016/s1535-6108(04)00081-9
Bao, Shideng, Gaoliang Ouyang, Xuefang Bai, Zhi Huang, Chaoyu Ma, Ming Liu, Rong Shao, Ryan M. Anderson, Jeremy N. Rich, and Xiao-Fan Wang. “Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.Cancer Cell 5, no. 4 (April 2004): 329–39. https://doi.org/10.1016/s1535-6108(04)00081-9.
Bao S, Ouyang G, Bai X, Huang Z, Ma C, Liu M, et al. Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell. 2004 Apr;5(4):329–39.
Bao, Shideng, et al. “Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.Cancer Cell, vol. 5, no. 4, Apr. 2004, pp. 329–39. Pubmed, doi:10.1016/s1535-6108(04)00081-9.
Bao S, Ouyang G, Bai X, Huang Z, Ma C, Liu M, Shao R, Anderson RM, Rich JN, Wang X-F. Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell. 2004 Apr;5(4):329–339.
Journal cover image

Published In

Cancer Cell

DOI

ISSN

1535-6108

Publication Date

April 2004

Volume

5

Issue

4

Start / End Page

329 / 339

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Signal Transduction
  • Proto-Oncogene Proteins c-akt
  • Proto-Oncogene Proteins
  • Protein Serine-Threonine Kinases
  • Oncology & Carcinogenesis
  • Mice, Nude
  • Mice
  • Liver Neoplasms
  • Integrin alphaVbeta3