Smads "freeze" when they ski.


Journal Article (Review)

The transforming growth factor-beta (TGF-beta) signal is manifest through activated heteromeric Smad complex-mediated transcriptional modulation of target genes that translates into diverse, context-specific biologic effects, such as the potent TGF-beta-initiated cytostatic program. The TGF-beta pathway is effectively antagonized through the direct binding and subsequent repression of activated Smad heteromeric complexes by the Ski family of proto-oncoproteins.

Full Text

Duke Authors

Cited Authors

  • Frederick, JP; Wang, X-F

Published Date

  • December 2002

Published In

Volume / Issue

  • 10 / 12

Start / End Page

  • 1607 - 1611

PubMed ID

  • 12467567

Pubmed Central ID

  • 12467567

International Standard Serial Number (ISSN)

  • 0969-2126

Digital Object Identifier (DOI)

  • 10.1016/s0969-2126(02)00914-0


  • eng

Conference Location

  • United States