A transforming growth factor beta type I receptor that signals to activate gene expression.


Journal Article

Transforming growth factor beta (TGF-beta) is a multifunctional factor that regulates many aspects of cellular functions. TGF-beta signals through a heteromeric complex of the type I and type II TGF-beta receptors. However, the molecular mechanism of signal transduction by this receptor complex remains unresolved. The type II receptor belongs to a transmembrane receptor serine-threonine kinase family. A new member of this receptor family (R4) was identified and shown to be a functional TGF-beta type I receptor on the basis of its ability to restore a TGF-beta-induced gene response in mutant cell lines lacking endogenous type I receptor. Both ligand binding and signaling of the R4 protein were dependent on the presence of a functional type II receptor. The type I receptor has an intrinsic serine-threonine kinase activity, which was essential for signal transduction.

Full Text

Duke Authors

Cited Authors

  • Bassing, CH; Yingling, JM; Howe, DJ; Wang, T; He, WW; Gustafson, ML; Shah, P; Donahoe, PK; Wang, XF

Published Date

  • January 7, 1994

Published In

Volume / Issue

  • 263 / 5143

Start / End Page

  • 87 - 89

PubMed ID

  • 8272871

Pubmed Central ID

  • 8272871

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.8272871


  • eng

Conference Location

  • United States