Design and inference for cancer biomarker study with an outcome and auxiliary-dependent subsampling.

Journal Article (Journal Article)

In cancer research, it is important to evaluate the performance of a biomarker (e.g., molecular, genetic, or imaging) that correlates patients' prognosis or predicts patients' response to treatment in a large prospective study. Due to overall budget constraint and high cost associated with bioassays, investigators often have to select a subset from all registered patients for biomarker assessment. To detect a potentially moderate association between the biomarker and the outcome, investigators need to decide how to select the subset of a fixed size such that the study efficiency can be enhanced. We show that, instead of drawing a simple random sample from the study cohort, greater efficiency can be achieved by allowing the selection probability to depend on the outcome and an auxiliary variable; we refer to such a sampling scheme as outcome and auxiliary-dependent subsampling (OADS). This article is motivated by the need to analyze data from a lung cancer biomarker study that adopts the OADS design to assess epidermal growth factor receptor (EGFR) mutations as a predictive biomarker for whether a subject responds to a greater extent to EGFR inhibitor drugs. We propose an estimated maximum-likelihood method that accommodates the OADS design and utilizes all observed information, especially those contained in the likelihood score of EGFR mutations (an auxiliary variable of EGFR mutations) that is available to all patients. We derive the asymptotic properties of the proposed estimator and evaluate its finite sample properties via simulation. We illustrate the proposed method with a data example.

Full Text

Duke Authors

Cited Authors

  • Wang, X; Zhou, H

Published Date

  • June 2010

Published In

Volume / Issue

  • 66 / 2

Start / End Page

  • 502 - 511

PubMed ID

  • 19508239

Pubmed Central ID

  • PMC2891224

Electronic International Standard Serial Number (EISSN)

  • 1541-0420

Digital Object Identifier (DOI)

  • 10.1111/j.1541-0420.2009.01280.x


  • eng

Conference Location

  • United States