Accessing long-lived nuclear singlet states between chemically equivalent spins without breaking symmetry.

Journal Article (Journal Article)

Long-lived nuclear spin states could greatly enhance the applicability of hyperpolarized nuclear magnetic resonance. Using singlet states between inequivalent spin pairs has been shown to extend the signal lifetime by more than an order of magnitude compared to the spin lattice relaxation time (T 1 ), but they have to be prevented from evolving into other states. In the most interesting case the singlet is between chemically equivalent spins, as it can then be inherently an eigenstate. However this presents major challenges in the conversion from bulk magnetization to singlet. In the only case demonstrated so far, a reversible chemical reaction to break symmetry was required. Here we present a pulse sequence technique that interconverts between singlet spin order and bulk magnetization without breaking the symmetry of the spin system. This technique is independent of field strength and is applicable to a broad range of molecules.

Full Text

Duke Authors

Cited Authors

  • Feng, Y; Davis, RM; Warren, WS

Published Date

  • November 2012

Published In

Volume / Issue

  • 8 / 11

Start / End Page

  • 831 - 837

PubMed ID

  • 23505397

Pubmed Central ID

  • PMC3596050

International Standard Serial Number (ISSN)

  • 1745-2473

Digital Object Identifier (DOI)

  • 10.1038/nphys2425


  • eng