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Detection of iron-labeled single cells by MR imaging based on intermolecular double quantum coherences at 14 T.

Publication ,  Journal Article
Cho, J-H; Hong, KS; Cho, J; Chang, S-K; Cheong, C; Lee, NH; Kim, H; Warren, WS; Ahn, S; Lee, C
Published in: Journal of magnetic resonance (San Diego, Calif. : 1997)
April 2012

To evaluate the efficiency and feasibility of intermolecular multiple quantum coherence (iMQC) magnetic resonance (MR) imaging for single cell detection, we obtained intermolecular double quantum coherence (iDQC) and conventional gradient echo (GE) images of macrophage cells labeled by contrast agents in gel. The iDQC images obtained with echo-planar readout visualized the labeled cells effectively and with a higher contrast than seen in conventional GE images, especially at low planar resolutions and with thick slices. This implies that iDQC imaging with contrast agents could be a good alternative to conventional MR imaging for detecting labeled single cells or cell tracking under favorable conditions.

Duke Scholars

Published In

Journal of magnetic resonance (San Diego, Calif. : 1997)

DOI

EISSN

1096-0856

ISSN

1090-7807

Publication Date

April 2012

Volume

217

Start / End Page

86 / 91

Related Subject Headings

  • Staining and Labeling
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Mice
  • Magnetite Nanoparticles
  • Magnetic Resonance Imaging
  • Macrophages
  • Dextrans
  • Contrast Media
  • Cell Tracking
 

Citation

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Cho, J.-H., Hong, K. S., Cho, J., Chang, S.-K., Cheong, C., Lee, N. H., … Lee, C. (2012). Detection of iron-labeled single cells by MR imaging based on intermolecular double quantum coherences at 14 T. Journal of Magnetic Resonance (San Diego, Calif. : 1997), 217, 86–91. https://doi.org/10.1016/j.jmr.2012.02.014
Cho, Jee-Hyun, Kwan Soo Hong, Janggeun Cho, Suk-Kyu Chang, Chaejoon Cheong, Na Hee Lee, Hyeonjin Kim, Warren S. Warren, Sangdoo Ahn, and Chulhyun Lee. “Detection of iron-labeled single cells by MR imaging based on intermolecular double quantum coherences at 14 T.Journal of Magnetic Resonance (San Diego, Calif. : 1997) 217 (April 2012): 86–91. https://doi.org/10.1016/j.jmr.2012.02.014.
Cho J-H, Hong KS, Cho J, Chang S-K, Cheong C, Lee NH, et al. Detection of iron-labeled single cells by MR imaging based on intermolecular double quantum coherences at 14 T. Journal of magnetic resonance (San Diego, Calif : 1997). 2012 Apr;217:86–91.
Cho, Jee-Hyun, et al. “Detection of iron-labeled single cells by MR imaging based on intermolecular double quantum coherences at 14 T.Journal of Magnetic Resonance (San Diego, Calif. : 1997), vol. 217, Apr. 2012, pp. 86–91. Epmc, doi:10.1016/j.jmr.2012.02.014.
Cho J-H, Hong KS, Cho J, Chang S-K, Cheong C, Lee NH, Kim H, Warren WS, Ahn S, Lee C. Detection of iron-labeled single cells by MR imaging based on intermolecular double quantum coherences at 14 T. Journal of magnetic resonance (San Diego, Calif : 1997). 2012 Apr;217:86–91.
Journal cover image

Published In

Journal of magnetic resonance (San Diego, Calif. : 1997)

DOI

EISSN

1096-0856

ISSN

1090-7807

Publication Date

April 2012

Volume

217

Start / End Page

86 / 91

Related Subject Headings

  • Staining and Labeling
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Mice
  • Magnetite Nanoparticles
  • Magnetic Resonance Imaging
  • Macrophages
  • Dextrans
  • Contrast Media
  • Cell Tracking