Detection of iron-labeled single cells by MR imaging based on intermolecular double quantum coherences at 14 T.

Journal Article (Journal Article)

To evaluate the efficiency and feasibility of intermolecular multiple quantum coherence (iMQC) magnetic resonance (MR) imaging for single cell detection, we obtained intermolecular double quantum coherence (iDQC) and conventional gradient echo (GE) images of macrophage cells labeled by contrast agents in gel. The iDQC images obtained with echo-planar readout visualized the labeled cells effectively and with a higher contrast than seen in conventional GE images, especially at low planar resolutions and with thick slices. This implies that iDQC imaging with contrast agents could be a good alternative to conventional MR imaging for detecting labeled single cells or cell tracking under favorable conditions.

Full Text

Duke Authors

Cited Authors

  • Cho, J-H; Hong, KS; Cho, J; Chang, S-K; Cheong, C; Lee, NH; Kim, H; Warren, WS; Ahn, S; Lee, C

Published Date

  • April 2012

Published In

Volume / Issue

  • 217 /

Start / End Page

  • 86 - 91

PubMed ID

  • 22436467

Pubmed Central ID

  • PMC3794080

Electronic International Standard Serial Number (EISSN)

  • 1096-0856

International Standard Serial Number (ISSN)

  • 1090-7807

Digital Object Identifier (DOI)

  • 10.1016/j.jmr.2012.02.014


  • eng