iDQC anisotropy map imaging for tumor tissue characterization in vivo.

Journal Article (Journal Article)

Intermolecular double quantum coherences (iDQCs), signals that result from simultaneous transitions of two or more separated spins, are known to produce images that are highly sensitive to subvoxel structure, particularly local anisotropy. Here we demonstrate how iDQCs signal can be used to efficiently detect the anisotropy created in breast tumor tissues and prostate tumor tissues by targeted (LHRH-conjugated) superparamagnetic nanoparticles (SPIONs), thereby distinguishing the necrotic area from the surrounding tumor tissue.

Full Text

Duke Authors

Cited Authors

  • Branca, RT; Chen, YM; Mouraviev, V; Galiana, G; Jenista, ER; Kumar, C; Leuschner, C; Warren, WS

Published Date

  • April 2009

Published In

Volume / Issue

  • 61 / 4

Start / End Page

  • 937 - 943

PubMed ID

  • 19215050

Pubmed Central ID

  • PMC2798128

Electronic International Standard Serial Number (EISSN)

  • 1522-2594

International Standard Serial Number (ISSN)

  • 0740-3194

Digital Object Identifier (DOI)

  • 10.1002/mrm.21925


  • eng