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Optimized, unequal pulse spacing in multiple echo sequences improves refocusing in magnetic resonance.

Publication ,  Journal Article
Jenista, ER; Stokes, AM; Branca, RT; Warren, WS
Published in: The Journal of chemical physics
November 2009

A recent quantum computing paper (G. S. Uhrig, Phys. Rev. Lett. 98, 100504 (2007)) analytically derived optimal pulse spacings for a multiple spin echo sequence designed to remove decoherence in a two-level system coupled to a bath. The spacings in what has been called a "Uhrig dynamic decoupling (UDD) sequence" differ dramatically from the conventional, equal pulse spacing of a Carr-Purcell-Meiboom-Gill (CPMG) multiple spin echo sequence. The UDD sequence was derived for a model that is unrelated to magnetic resonance, but was recently shown theoretically to be more general. Here we show that the UDD sequence has theoretical advantages for magnetic resonance imaging of structured materials such as tissue, where diffusion in compartmentalized and microstructured environments leads to fluctuating fields on a range of different time scales. We also show experimentally, both in excised tissue and in a live mouse tumor model, that optimal UDD sequences produce different T(2)-weighted contrast than do CPMG sequences with the same number of pulses and total delay, with substantial enhancements in most regions. This permits improved characterization of low-frequency spectral density functions in a wide range of applications.

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Published In

The Journal of chemical physics

DOI

EISSN

1089-7690

ISSN

0021-9606

Publication Date

November 2009

Volume

131

Issue

20

Start / End Page

204510

Related Subject Headings

  • Mice
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Health Care Reform
  • Contrast Media
  • Chemical Physics
  • Animals
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
 

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Jenista, E. R., Stokes, A. M., Branca, R. T., & Warren, W. S. (2009). Optimized, unequal pulse spacing in multiple echo sequences improves refocusing in magnetic resonance. The Journal of Chemical Physics, 131(20), 204510. https://doi.org/10.1063/1.3263196
Jenista, Elizabeth R., Ashley M. Stokes, Rosa Tamara Branca, and Warren S. Warren. “Optimized, unequal pulse spacing in multiple echo sequences improves refocusing in magnetic resonance.The Journal of Chemical Physics 131, no. 20 (November 2009): 204510. https://doi.org/10.1063/1.3263196.
Jenista ER, Stokes AM, Branca RT, Warren WS. Optimized, unequal pulse spacing in multiple echo sequences improves refocusing in magnetic resonance. The Journal of chemical physics. 2009 Nov;131(20):204510.
Jenista, Elizabeth R., et al. “Optimized, unequal pulse spacing in multiple echo sequences improves refocusing in magnetic resonance.The Journal of Chemical Physics, vol. 131, no. 20, Nov. 2009, p. 204510. Epmc, doi:10.1063/1.3263196.
Jenista ER, Stokes AM, Branca RT, Warren WS. Optimized, unequal pulse spacing in multiple echo sequences improves refocusing in magnetic resonance. The Journal of chemical physics. 2009 Nov;131(20):204510.

Published In

The Journal of chemical physics

DOI

EISSN

1089-7690

ISSN

0021-9606

Publication Date

November 2009

Volume

131

Issue

20

Start / End Page

204510

Related Subject Headings

  • Mice
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Health Care Reform
  • Contrast Media
  • Chemical Physics
  • Animals
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences