Accurate temperature imaging based on intermolecular coherences in magnetic resonance.

Journal Article (Journal Article)

Conventional magnetic resonance methods that provide interior temperature profiles, which find use in clinical applications such as hyperthermic therapy, can develop inaccuracies caused by the inherently inhomogeneous magnetic field within tissues or by probe dynamics, and work poorly in important applications such as fatty tissues. We present a magnetic resonance method that is suitable for imaging temperature in a wide range of environments. It uses the inherently sharp resonances of intermolecular zero-quantum coherences, in this case flipping up a water spin while flipping down a nearby fat spin. We show that this method can rapidly and accurately assign temperatures in vivo on an absolute scale.

Full Text

Duke Authors

Cited Authors

  • Galiana, G; Branca, RT; Jenista, ER; Warren, WS

Published Date

  • October 2008

Published In

Volume / Issue

  • 322 / 5900

Start / End Page

  • 421 - 424

PubMed ID

  • 18927389

Pubmed Central ID

  • PMC3080759

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1163242


  • eng