Reduced beta 2-receptor mediated vasodilation in African Americans.

Journal Article (Journal Article)

It is well recognized that African Americans have a higher prevalence of cardiovascular disease than White Americans although the underlying mechanisms are not entirely understood. This study was perfumed to evaluate racial differences in the chronotropic and vasodilatory effects of the beta-receptor agonist, isoproterenol. We compared cardiovascular responses to intravenous infusion of isoproterenol in 27 African Americans and 27 White men and women. African Americans showed significantly smaller beta 2-receptor mediated falls in diastolic pressure than Whites. In contrast, isoproterenol produced similar increases in heart rate in both races. The findings suggest that African Americans have decreased beta 2-receptor mediated vasodilatory capacity, and may help explain the higher prevalence of hypertension and cardiovascular disease in African Americans compared to Whites.

Full Text

Duke Authors

Cited Authors

  • Watkins, LL; Dimsdale, JE; Ziegler, MG

Published Date

  • 1995

Published In

Volume / Issue

  • 57 / 15

Start / End Page

  • 1411 - 1416

PubMed ID

  • 7674831

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(95)02103-p


  • eng

Conference Location

  • Netherlands