Assessment of baroreflex control from beat-to-beat blood pressure and heart rate changes: a validation study.

Journal Article (Clinical Trial;Journal Article)

In this study, we tested the validity of a new method designed to estimate baroreflex control of heart rate from spontaneous changes in systolic pressure and pulse interval. This method was compared with a conventional method of assessing baroreflex control through measuring reflex adjustments in pulse interval associated with pharmacological manipulations of blood pressure. The estimates of baroreflex control derived from the two methods were significantly correlated; however, only the estimate derived using pharmacological changes in pressure detected significant impairment of baroreflex control in patients with damage to baroafferents produced by radiation for oropharyngeal cancer. Analysis of spontaneous changes in pressure and pulse interval therefore provide a meaningful estimate of baroreflex control of heart rate that is, however, less sensitive than estimates obtained using pharmacological manipulations in pressure.

Full Text

Duke Authors

Cited Authors

  • Watkins, LL; Fainman, C; Dimsdale, J; Ziegler, MG

Published Date

  • July 1995

Published In

Volume / Issue

  • 32 / 4

Start / End Page

  • 411 - 414

PubMed ID

  • 7652118

International Standard Serial Number (ISSN)

  • 0048-5772

Digital Object Identifier (DOI)

  • 10.1111/j.1469-8986.1995.tb01224.x


  • eng

Conference Location

  • United States