Multispectral nanoparticle contrast agents for true-color spectroscopic optical coherence tomography.

Journal Article (Journal Article)

We have recently developed a novel dual window scheme for processing spectroscopic OCT images to provide spatially resolved true color imaging of chromophores in scattering samples. Here we apply this method to measure the extinction spectra of plasmonic nanoparticles at various concentrations for potential in vivo applications. We experimentally demonstrate sub-nanomolar sensitivity in the measurement of nanoparticle concentrations, and show that colorimetric imaging with multiple species of nanoparticles produces enhanced contrast for spectroscopic OCT in both tissue phantom and cell studies.

Full Text

Duke Authors

Cited Authors

  • Li, YL; Seekell, K; Yuan, H; Robles, FE; Wax, A

Published Date

  • August 2012

Published In

Volume / Issue

  • 3 / 8

Start / End Page

  • 1914 - 1923

PubMed ID

  • 22876354

Pubmed Central ID

  • 22876354

Electronic International Standard Serial Number (EISSN)

  • 2156-7085

International Standard Serial Number (ISSN)

  • 2156-7085

Digital Object Identifier (DOI)

  • 10.1364/boe.3.001914


  • eng