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Detection of early colorectal cancer development in the azoxymethane rat carcinogenesis model with Fourier domain low coherence interferometry.

Publication ,  Journal Article
Robles, FE; Zhu, Y; Lee, J; Sharma, S; Wax, A
Published in: Biomedical optics express
August 2010

Fourier domain low coherence interferometry (fLCI) is an emerging optical technique used to quantitatively assess cell nuclear morphology in tissue as a means of detecting early cancer development. In this work, we use the azoxymethane rat carcinogenesis model, a well characterized and established model for colon cancer research, to demonstrate the ability of fLCI to distinguish between normal and preneoplastic ex-vivo colon tissue. The results show highly statistically significant differences between the measured cell nuclear diameters of normal and azoxymethane-treated tissues, thus providing strong evidence that fLCI may be a powerful tool for non-invasive, quantitative detection of early changes associated with colorectal cancer development.

Duke Scholars

Published In

Biomedical optics express

DOI

EISSN

2156-7085

ISSN

2156-7085

Publication Date

August 2010

Volume

1

Issue

2

Start / End Page

736 / 745

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics
 

Citation

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ICMJE
MLA
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Robles, F. E., Zhu, Y., Lee, J., Sharma, S., & Wax, A. (2010). Detection of early colorectal cancer development in the azoxymethane rat carcinogenesis model with Fourier domain low coherence interferometry. Biomedical Optics Express, 1(2), 736–745. https://doi.org/10.1364/boe.1.000736
Robles, Francisco E., Yizheng Zhu, Jin Lee, Sheela Sharma, and Adam Wax. “Detection of early colorectal cancer development in the azoxymethane rat carcinogenesis model with Fourier domain low coherence interferometry.Biomedical Optics Express 1, no. 2 (August 2010): 736–45. https://doi.org/10.1364/boe.1.000736.
Robles, Francisco E., et al. “Detection of early colorectal cancer development in the azoxymethane rat carcinogenesis model with Fourier domain low coherence interferometry.Biomedical Optics Express, vol. 1, no. 2, Aug. 2010, pp. 736–45. Epmc, doi:10.1364/boe.1.000736.
Journal cover image

Published In

Biomedical optics express

DOI

EISSN

2156-7085

ISSN

2156-7085

Publication Date

August 2010

Volume

1

Issue

2

Start / End Page

736 / 745

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics