Detection of early colorectal cancer development in the azoxymethane rat carcinogenesis model with Fourier domain low coherence interferometry.

Journal Article (Journal Article)

Fourier domain low coherence interferometry (fLCI) is an emerging optical technique used to quantitatively assess cell nuclear morphology in tissue as a means of detecting early cancer development. In this work, we use the azoxymethane rat carcinogenesis model, a well characterized and established model for colon cancer research, to demonstrate the ability of fLCI to distinguish between normal and preneoplastic ex-vivo colon tissue. The results show highly statistically significant differences between the measured cell nuclear diameters of normal and azoxymethane-treated tissues, thus providing strong evidence that fLCI may be a powerful tool for non-invasive, quantitative detection of early changes associated with colorectal cancer development.

Full Text

Duke Authors

Cited Authors

  • Robles, FE; Zhu, Y; Lee, J; Sharma, S; Wax, A

Published Date

  • August 25, 2010

Published In

Volume / Issue

  • 1 / 2

Start / End Page

  • 736 - 745

PubMed ID

  • 21258505

Pubmed Central ID

  • PMC3017982

Electronic International Standard Serial Number (EISSN)

  • 2156-7085

International Standard Serial Number (ISSN)

  • 2156-7085

Digital Object Identifier (DOI)

  • 10.1364/boe.1.000736


  • eng