Assessing hemoglobin concentration using spectroscopic optical coherence tomography for feasibility of tissue diagnostics.

Published

Journal Article

Hemoglobin (Hb) concentration and oxygen saturation levels are important biomarkers for various diseases, including cancer. Here, we investigate the ability to measure these parameters for tissue using spectroscopic optical coherence tomography (SOCT). A parallel frequency domain OCT system is used with detection spanning the visible region of the spectrum (450 nm to 700 nm). Oxygenated and deoxygenated Hb absorbing phantoms are analyzed. The results show that Hb concentrations as low as 1.2 g/L at 1 mm can be retrieved indicating that both normal and cancerous tissue measurements may be obtained. However, measurement of oxygen saturation levels may not be achieved with this approach.

Full Text

Duke Authors

Cited Authors

  • Robles, FE; Chowdhury, S; Wax, A

Published Date

  • July 27, 2010

Published In

Volume / Issue

  • 1 / 1

Start / End Page

  • 310 - 317

PubMed ID

  • 21258468

Pubmed Central ID

  • 21258468

Electronic International Standard Serial Number (EISSN)

  • 2156-7085

International Standard Serial Number (ISSN)

  • 2156-7085

Digital Object Identifier (DOI)

  • 10.1364/boe.1.000310/

Language

  • eng