Skip to main content

Development of a clinical Fourier-domain angle resolved low coherence interferometry system for in vivo measurements

Publication ,  Journal Article
Terry, NG; Zhu, Y; Brown, WJ; Wax, A
Published in: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
April 21, 2008

Improved methods for detecting dysplasia, or pre-cancerous growth are a current clinical need, particularly in the esophagus. The currently accepted method of random biopsy and histological analysis provides only a limited examination of tissue in question while being coupled with a long time delay for diagnosis. Optical scattering spectroscopy, in contrast, allows for inspection of the cellular structure and organization of tissue in vivo. Fourier-domain angle-resolved low-coherence interferometry (a/LCI) is a novel scattering spectroscopy technique that provides quantitative depth-resolved morphological measurements of the size and optical density of the examined cell nuclei, which are characteristic biomarkers of dysplasia. Previously, the clinical viability of the a/LCI system was demonstrated by analysis of ex vivo human esophageal tissue in Barrett's esophagus patients using a portable a/LCI system. We present an adaptation of the portable a/LCI instrument that can be used in the accessory channel of a gastroscope, allowing for in vivo measurements to be taken. Modifications to the previous generation system include the use of an improved imaging spectrometer allowing for subsecond acquisition times and the redesign of the delivery fiber and imaging optics in order to fit in the accessory channel of a gastroscope. Accurate sizing of polystyrene microspheres and other preliminary results are presented, demonstrating promise as a clinically viable tool.

Duke Scholars

Published In

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

DOI

ISSN

1605-7422

Publication Date

April 21, 2008

Volume

6864
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Terry, N. G., Zhu, Y., Brown, W. J., & Wax, A. (2008). Development of a clinical Fourier-domain angle resolved low coherence interferometry system for in vivo measurements. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 6864. https://doi.org/10.1117/12.763782
Terry, N. G., Y. Zhu, W. J. Brown, and A. Wax. “Development of a clinical Fourier-domain angle resolved low coherence interferometry system for in vivo measurements.” Progress in Biomedical Optics and Imaging - Proceedings of SPIE 6864 (April 21, 2008). https://doi.org/10.1117/12.763782.
Terry NG, Zhu Y, Brown WJ, Wax A. Development of a clinical Fourier-domain angle resolved low coherence interferometry system for in vivo measurements. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2008 Apr 21;6864.
Terry, N. G., et al. “Development of a clinical Fourier-domain angle resolved low coherence interferometry system for in vivo measurements.” Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6864, Apr. 2008. Scopus, doi:10.1117/12.763782.
Terry NG, Zhu Y, Brown WJ, Wax A. Development of a clinical Fourier-domain angle resolved low coherence interferometry system for in vivo measurements. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2008 Apr 21;6864.

Published In

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

DOI

ISSN

1605-7422

Publication Date

April 21, 2008

Volume

6864