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Effects of transdermal testosterone gel on bone turnover markers and bone mineral density in hypogonadal men.

Publication ,  Journal Article
Wang, C; Swerdloff, RS; Iranmanesh, A; Dobs, A; Snyder, PJ; Cunningham, G; Matsumoto, AM; Weber, T; Berman, N
Published in: Clin Endocrinol (Oxf)
June 2001

OBJECTIVE: Androgen replacement has been reported to increase bone mineral density (BMD) in hypogonadal men. We studied the effects of 6 months of treatment with a new transdermal testosterone (T) gel preparation on bone turnover markers and BMD. DESIGN: This was a prospective, randomized, multicentre, parallel clinical trial where 227 hypogonadal men, mean age 51 years (range: 19-68 years) were studied in 16 academic and research institutions in the USA. Subjects were randomized to apply 1% T gel containing 50 or 100 mg T (delivering approximately 5-10 mg T/day) or two T patches (delivering 5 mg T/day) transdermally for 90 days. At day 91, depending on the serum T concentration, the T gel dose was adjusted upward or downward to 75 mg T/day until day 180. No dose adjustment occurred in the T patch group. MEASUREMENTS: Serum T, free T and oestradiol, bone turnover markers and BMD were measured on days 0, 30, 90 and 180 before and after treatment. RESULTS: Application of T gel 100 mg/day resulted in serum T concentrations 1.4 and 1.9-fold higher than in the T gel 50 mg/day and the T patch groups, respectively. Proportional increases occurred in serum oestradiol. Urine N-telopeptide/creatinine ratio, a marker for bone resorption, decreased significantly (P = 0.0019) only in the T gel 100 mg/day group. Serum bone osteoblastic activity markers (osteocalcin, procollagen and skeletal alkaline phosphatase) increased significantly during the first 90 days of treatment without intergroup differences but declined to baseline thereafter. BMD increased significantly both in the hip (+1.1 +/- 0.3%) and spine (+2.2 +/- 0.5%) only in the T gel 100 mg/day group (P = 0.0001). CONCLUSIONS: Transdermal testosterone gel application for 6 months decreased bone resorption markers and increased osteoblastic activity markers for a short period, which resulted in a small but significant increase in BMD. Ongoing long-term studies should answer whether the observed increases in BMD are sustained or continue to be dependent on the dose of testosterone administered.

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Published In

Clin Endocrinol (Oxf)

DOI

ISSN

0300-0664

Publication Date

June 2001

Volume

54

Issue

6

Start / End Page

739 / 750

Location

England

Related Subject Headings

  • Testosterone
  • Prospective Studies
  • Procollagen
  • Phosphorus
  • Peptides
  • Osteocalcin
  • Middle Aged
  • Male
  • Hypogonadism
  • Humans
 

Citation

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Wang, C., Swerdloff, R. S., Iranmanesh, A., Dobs, A., Snyder, P. J., Cunningham, G., … Berman, N. (2001). Effects of transdermal testosterone gel on bone turnover markers and bone mineral density in hypogonadal men. Clin Endocrinol (Oxf), 54(6), 739–750. https://doi.org/10.1046/j.1365-2265.2001.01271.x
Wang, C., R. S. Swerdloff, A. Iranmanesh, A. Dobs, P. J. Snyder, G. Cunningham, A. M. Matsumoto, T. Weber, and N. Berman. “Effects of transdermal testosterone gel on bone turnover markers and bone mineral density in hypogonadal men.Clin Endocrinol (Oxf) 54, no. 6 (June 2001): 739–50. https://doi.org/10.1046/j.1365-2265.2001.01271.x.
Wang C, Swerdloff RS, Iranmanesh A, Dobs A, Snyder PJ, Cunningham G, et al. Effects of transdermal testosterone gel on bone turnover markers and bone mineral density in hypogonadal men. Clin Endocrinol (Oxf). 2001 Jun;54(6):739–50.
Wang, C., et al. “Effects of transdermal testosterone gel on bone turnover markers and bone mineral density in hypogonadal men.Clin Endocrinol (Oxf), vol. 54, no. 6, June 2001, pp. 739–50. Pubmed, doi:10.1046/j.1365-2265.2001.01271.x.
Wang C, Swerdloff RS, Iranmanesh A, Dobs A, Snyder PJ, Cunningham G, Matsumoto AM, Weber T, Berman N. Effects of transdermal testosterone gel on bone turnover markers and bone mineral density in hypogonadal men. Clin Endocrinol (Oxf). 2001 Jun;54(6):739–750.
Journal cover image

Published In

Clin Endocrinol (Oxf)

DOI

ISSN

0300-0664

Publication Date

June 2001

Volume

54

Issue

6

Start / End Page

739 / 750

Location

England

Related Subject Headings

  • Testosterone
  • Prospective Studies
  • Procollagen
  • Phosphorus
  • Peptides
  • Osteocalcin
  • Middle Aged
  • Male
  • Hypogonadism
  • Humans