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A quantitatively controlled method to study prospectively interstitial cystitis and demonstrate the efficacy of pentosanpolysulfate.

Publication ,  Journal Article
Parsons, CL; Benson, G; Childs, SJ; Hanno, P; Sant, GR; Webster, G
Published in: J Urol
September 1993

A randomized, prospective, double-blind, placebo-controlled study was conducted at 7 clinical centers on 148 patients. Patients received orally either 100 mg. pentosanpolysulfate (a synthetic polysaccharide) 3 times per day or a placebo. Of the patients on drug therapy 32% showed significant improvement compared to 16% of those on placebo (p = 0.01). This study provides a model to assess this disease quantitatively in a prospective manner using a method whereby the patients globally assess their symptoms as either worse or improved by 0, 25, 50, 75 or 100%. Patients on drug therapy also experienced a significant decrease in pain and urgency (p = 0.04 and 0.01) on analogue scales when compared to placebo and also more drug patients showed an average increase of more than 20 ml. in voided volume than did placebo patients (p = 0.02). All adverse effects were minor, with 7 in the drug group and 10 in the placebo group. The results support the concept that some patients with the interstitial cystitis syndrome may have abnormal bladder surface glycosaminoglycans.

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Published In

J Urol

DOI

ISSN

0022-5347

Publication Date

September 1993

Volume

150

Issue

3

Start / End Page

845 / 848

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Research Design
  • Prospective Studies
  • Pentosan Sulfuric Polyester
  • Middle Aged
  • Male
  • Humans
  • Female
  • Double-Blind Method
  • Cystitis
 

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Parsons, C. L., Benson, G., Childs, S. J., Hanno, P., Sant, G. R., & Webster, G. (1993). A quantitatively controlled method to study prospectively interstitial cystitis and demonstrate the efficacy of pentosanpolysulfate. J Urol, 150(3), 845–848. https://doi.org/10.1016/s0022-5347(17)35629-x
Parsons, C. L., G. Benson, S. J. Childs, P. Hanno, G. R. Sant, and G. Webster. “A quantitatively controlled method to study prospectively interstitial cystitis and demonstrate the efficacy of pentosanpolysulfate.J Urol 150, no. 3 (September 1993): 845–48. https://doi.org/10.1016/s0022-5347(17)35629-x.
Parsons CL, Benson G, Childs SJ, Hanno P, Sant GR, Webster G. A quantitatively controlled method to study prospectively interstitial cystitis and demonstrate the efficacy of pentosanpolysulfate. J Urol. 1993 Sep;150(3):845–8.
Parsons, C. L., et al. “A quantitatively controlled method to study prospectively interstitial cystitis and demonstrate the efficacy of pentosanpolysulfate.J Urol, vol. 150, no. 3, Sept. 1993, pp. 845–48. Pubmed, doi:10.1016/s0022-5347(17)35629-x.
Parsons CL, Benson G, Childs SJ, Hanno P, Sant GR, Webster G. A quantitatively controlled method to study prospectively interstitial cystitis and demonstrate the efficacy of pentosanpolysulfate. J Urol. 1993 Sep;150(3):845–848.
Journal cover image

Published In

J Urol

DOI

ISSN

0022-5347

Publication Date

September 1993

Volume

150

Issue

3

Start / End Page

845 / 848

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Research Design
  • Prospective Studies
  • Pentosan Sulfuric Polyester
  • Middle Aged
  • Male
  • Humans
  • Female
  • Double-Blind Method
  • Cystitis