Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease.

Journal Article (Journal Article)

BACKGROUND: Previous linkage studies have shown that chromosome 12 harbors susceptibility genes for late-onset Alzheimer disease (LOAD). However, association studies of several candidate genes on this chromosome region have produced ambiguous results. A recent study reported the association between the glyceraldehyde-3-phosphate dehydrogenase (GAPD) gene on chromosome 12p and the risk of LOAD. METHODS: The authors conducted family-based and case-control association studies in two independent LOAD data sets on 12 single-nucleotide polymorphisms (SNPs) in the GAPD gene and its paralogs. RESULTS: No association was found of the GAPD gene with LOAD in the family-based data set, but marginal evidence of association was seen in the later-onset subgroup when age at onset was stratified. The SNP rs2029721 in one GAPD pseudogene was also found to be associated with risk for LOAD in the unrelated case-control data set (p = 0.003). CONCLUSIONS: The GAPD gene and its pseudogene may play a role in the development of late-onset Alzheimer disease. However, the effect, if any, is likely to be limited.

Full Text

Duke Authors

Cited Authors

  • Lin, PI; Martin, ER; Bronson, PG; Browning-Large, C; Small, GW; Schmechel, DE; Welsh-Bohmer, KA; Haines, JL; Gilbert, JR; Pericak-Vance, MA

Published Date

  • July 11, 2006

Published In

Volume / Issue

  • 67 / 1

Start / End Page

  • 64 - 68

PubMed ID

  • 16832079

Electronic International Standard Serial Number (EISSN)

  • 1526-632X

Digital Object Identifier (DOI)

  • 10.1212/01.wnl.0000223438.90113.4e


  • eng

Conference Location

  • United States