Attenuation of epileptogenesis: proactive effect of a single epinephrine injection of amygdaloid kindling.

Journal Article (Journal Article)

Repeated daily electrical stimulation of the amygdala can lead to a progressive increase in brain and behavioral seizures. This phenomenon, termed kindling, has been viewed as a model for epileptogenesis. The results reported here demonstrate that a single systemic epinephrine injection can significantly retard such epileptogenesis for a period of at least several days. These findings suggest that peripheral catecholamines, responding either to stress near the time of seizure initiation or to treatments administered at that time, may be important in regulating the development of epileptic states. In addition, the results indicate that an acute episode of high plasma epinephrine levels may result in a durable modification of brain function.

Full Text

Duke Authors

Cited Authors

  • Welsh, KA; Gold, PE

Published Date

  • March 1, 1984

Published In

Volume / Issue

  • 40 / 2

Start / End Page

  • 179 - 185

PubMed ID

  • 6732711

International Standard Serial Number (ISSN)

  • 0163-1047

Digital Object Identifier (DOI)

  • 10.1016/s0163-1047(84)90279-6


  • eng

Conference Location

  • United States