Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury.

Journal Article

Substantial progress has been made in understanding the contribution of alterations in coagulation and fibrinolysis to the pathogenesis of acute lung injury (ALI). Findings from mouse, rat, baboon, and human studies indicate that alterations in coagulation and fibrinolysis may be of major pathogenetic importance in ALI and other inflammatory conditions in the lung including pneumonia, sepsis, and ventilator-induced lung injury. Therapies targeted at both activation of coagulation through the extrinsic coagulation cascade and modulation of coagulation through the protein C system have the potential to favorably impact clinical ALI/acute respiratory distress syndrome.

Full Text

Duke Authors

Cited Authors

  • Ware, LB; Camerer, E; Welty-Wolf, K; Schultz, MJ; Matthay, MA

Published Date

  • September 2006

Published In

Volume / Issue

  • 291 / 3

Start / End Page

  • L307 - L311

PubMed ID

  • 16648240

International Standard Serial Number (ISSN)

  • 1040-0605

Digital Object Identifier (DOI)

  • 10.1152/ajplung.00157.2006


  • eng

Conference Location

  • United States