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Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury.

Publication ,  Journal Article
Ware, LB; Camerer, E; Welty-Wolf, K; Schultz, MJ; Matthay, MA
Published in: Am J Physiol Lung Cell Mol Physiol
September 2006

Substantial progress has been made in understanding the contribution of alterations in coagulation and fibrinolysis to the pathogenesis of acute lung injury (ALI). Findings from mouse, rat, baboon, and human studies indicate that alterations in coagulation and fibrinolysis may be of major pathogenetic importance in ALI and other inflammatory conditions in the lung including pneumonia, sepsis, and ventilator-induced lung injury. Therapies targeted at both activation of coagulation through the extrinsic coagulation cascade and modulation of coagulation through the protein C system have the potential to favorably impact clinical ALI/acute respiratory distress syndrome.

Duke Scholars

Published In

Am J Physiol Lung Cell Mol Physiol

DOI

ISSN

1040-0605

Publication Date

September 2006

Volume

291

Issue

3

Start / End Page

L307 / L311

Location

United States

Related Subject Headings

  • Thromboplastin
  • Thrombomodulin
  • Sepsis
  • Respiratory System
  • Respiratory Distress Syndrome
  • Respiration, Artificial
  • Receptors, Proteinase-Activated
  • Protein C
  • Pneumonia
  • Papio
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ware, L. B., Camerer, E., Welty-Wolf, K., Schultz, M. J., & Matthay, M. A. (2006). Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury. Am J Physiol Lung Cell Mol Physiol, 291(3), L307–L311. https://doi.org/10.1152/ajplung.00157.2006
Ware, Lorraine B., Eric Camerer, Karen Welty-Wolf, Marcus J. Schultz, and Michael A. Matthay. “Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury.Am J Physiol Lung Cell Mol Physiol 291, no. 3 (September 2006): L307–11. https://doi.org/10.1152/ajplung.00157.2006.
Ware LB, Camerer E, Welty-Wolf K, Schultz MJ, Matthay MA. Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Sep;291(3):L307–11.
Ware, Lorraine B., et al. “Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury.Am J Physiol Lung Cell Mol Physiol, vol. 291, no. 3, Sept. 2006, pp. L307–11. Pubmed, doi:10.1152/ajplung.00157.2006.
Ware LB, Camerer E, Welty-Wolf K, Schultz MJ, Matthay MA. Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Sep;291(3):L307–L311.

Published In

Am J Physiol Lung Cell Mol Physiol

DOI

ISSN

1040-0605

Publication Date

September 2006

Volume

291

Issue

3

Start / End Page

L307 / L311

Location

United States

Related Subject Headings

  • Thromboplastin
  • Thrombomodulin
  • Sepsis
  • Respiratory System
  • Respiratory Distress Syndrome
  • Respiration, Artificial
  • Receptors, Proteinase-Activated
  • Protein C
  • Pneumonia
  • Papio