Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury.
Publication
, Journal Article
Ware, LB; Camerer, E; Welty-Wolf, K; Schultz, MJ; Matthay, MA
Published in: Am J Physiol Lung Cell Mol Physiol
September 2006
Substantial progress has been made in understanding the contribution of alterations in coagulation and fibrinolysis to the pathogenesis of acute lung injury (ALI). Findings from mouse, rat, baboon, and human studies indicate that alterations in coagulation and fibrinolysis may be of major pathogenetic importance in ALI and other inflammatory conditions in the lung including pneumonia, sepsis, and ventilator-induced lung injury. Therapies targeted at both activation of coagulation through the extrinsic coagulation cascade and modulation of coagulation through the protein C system have the potential to favorably impact clinical ALI/acute respiratory distress syndrome.
Duke Scholars
Published In
Am J Physiol Lung Cell Mol Physiol
DOI
ISSN
1040-0605
Publication Date
September 2006
Volume
291
Issue
3
Start / End Page
L307 / L311
Location
United States
Related Subject Headings
- Thromboplastin
- Thrombomodulin
- Sepsis
- Respiratory System
- Respiratory Distress Syndrome
- Respiration, Artificial
- Receptors, Proteinase-Activated
- Protein C
- Pneumonia
- Papio
Citation
APA
Chicago
ICMJE
MLA
NLM
Ware, L. B., Camerer, E., Welty-Wolf, K., Schultz, M. J., & Matthay, M. A. (2006). Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury. Am J Physiol Lung Cell Mol Physiol, 291(3), L307–L311. https://doi.org/10.1152/ajplung.00157.2006
Ware, Lorraine B., Eric Camerer, Karen Welty-Wolf, Marcus J. Schultz, and Michael A. Matthay. “Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury.” Am J Physiol Lung Cell Mol Physiol 291, no. 3 (September 2006): L307–11. https://doi.org/10.1152/ajplung.00157.2006.
Ware LB, Camerer E, Welty-Wolf K, Schultz MJ, Matthay MA. Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Sep;291(3):L307–11.
Ware, Lorraine B., et al. “Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury.” Am J Physiol Lung Cell Mol Physiol, vol. 291, no. 3, Sept. 2006, pp. L307–11. Pubmed, doi:10.1152/ajplung.00157.2006.
Ware LB, Camerer E, Welty-Wolf K, Schultz MJ, Matthay MA. Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Sep;291(3):L307–L311.
Published In
Am J Physiol Lung Cell Mol Physiol
DOI
ISSN
1040-0605
Publication Date
September 2006
Volume
291
Issue
3
Start / End Page
L307 / L311
Location
United States
Related Subject Headings
- Thromboplastin
- Thrombomodulin
- Sepsis
- Respiratory System
- Respiratory Distress Syndrome
- Respiration, Artificial
- Receptors, Proteinase-Activated
- Protein C
- Pneumonia
- Papio