Gene expression levels influence amino acid usage and evolutionary rates in endosymbiotic bacteria.
Published
Journal Article
Most endosymbiotic bacteria have extremely reduced genomes, accelerated evolutionary rates, and strong AT base compositional bias thought to reflect reduced efficacy of selection and increased mutational pressure. Here, we present a comparative study of evolutionary forces shaping five fully sequenced bacterial endosymbionts of insects. The results of this study were three-fold: (i) Stronger conservation of high expression genes at not just nonsynonymous, but also synonymous, sites. (ii) Variation in amino acid usage strongly correlates with GC content and expression level of genes. This pattern is largely explained by greater conservation of high expression genes, leading to their higher GC content. However, we also found indication of selection favoring GC-rich amino acids that contrasts with former studies. (iii) Although the specific nutritional requirements of the insect host are known to affect gene content of endosymbionts, we found no detectable influence on substitution rates, amino acid usage, or codon usage of bacterial genes involved in host nutrition.
Full Text
Duke Authors
Cited Authors
- Schaber, J; Rispe, C; Wernegreen, J; Buness, A; Delmotte, F; Silva, FJ; Moya, A
Published Date
- June 2005
Published In
Volume / Issue
- 352 /
Start / End Page
- 109 - 117
PubMed ID
- 15935576
Pubmed Central ID
- 15935576
Electronic International Standard Serial Number (EISSN)
- 1879-0038
International Standard Serial Number (ISSN)
- 0378-1119
Digital Object Identifier (DOI)
- 10.1016/j.gene.2005.04.003
Language
- eng