Lifestyle evolution in symbiotic bacteria: insights from genomics.


Journal Article

Bacteria that live only in eukaryotic cells and tissues, including chronic pathogens and mutualistic bacteriocyte associates, often possess a distinctive set of genomic traits, including reduced genome size, biased nucleotide base composition and fast polypeptide evolution. These phylogenetically diverse bacteria have lost certain functional categories of genes, including DNA repair genes, which affect mutational patterns. However, pathogens and mutualistic symbionts retain loci that underlie their unique interaction types, such as genes enabling nutrient provisioning by mutualistic bacteria-inhabiting animals. Recent genomic studies suggest that many of these bacteria are irreversibly specialized, precluding shifts between pathogenesis and mutualism.

Full Text

Duke Authors

Cited Authors

  • Moran, NA; Wernegreen, JJ

Published Date

  • August 2000

Published In

Volume / Issue

  • 15 / 8

Start / End Page

  • 321 - 326

PubMed ID

  • 10884696

Pubmed Central ID

  • 10884696

Electronic International Standard Serial Number (EISSN)

  • 1872-8383

International Standard Serial Number (ISSN)

  • 0169-5347

Digital Object Identifier (DOI)

  • 10.1016/s0169-5347(00)01902-9


  • eng