Regulated shuttling of the histone deacetylase HDAC5 to the nucleus may put a brake on cocaine addiction.
Published
Journal Article
The histone deacetylase HDAC5 has been shown to regulate behavioral adaptations to cocaine. In this issue of Neuron, Taniguchi et al. (2012) describe a cAMP-dependent signaling pathway that regulates nuclear accumulation of HDAC5, suggesting a mechanism to couple cocaine with changes in HDAC5 function.
Full Text
Duke Authors
Cited Authors
- West, AE
Published Date
- January 2012
Published In
Volume / Issue
- 73 / 1
Start / End Page
- 1 - 3
PubMed ID
- 22243740
Pubmed Central ID
- 22243740
Electronic International Standard Serial Number (EISSN)
- 1097-4199
International Standard Serial Number (ISSN)
- 0896-6273
Digital Object Identifier (DOI)
- 10.1016/j.neuron.2011.12.016
Language
- eng