Regulated shuttling of the histone deacetylase HDAC5 to the nucleus may put a brake on cocaine addiction.

Journal Article (Journal Article)

The histone deacetylase HDAC5 has been shown to regulate behavioral adaptations to cocaine. In this issue of Neuron, Taniguchi et al. (2012) describe a cAMP-dependent signaling pathway that regulates nuclear accumulation of HDAC5, suggesting a mechanism to couple cocaine with changes in HDAC5 function.

Full Text

Duke Authors

Cited Authors

  • West, AE

Published Date

  • January 12, 2012

Published In

Volume / Issue

  • 73 / 1

Start / End Page

  • 1 - 3

PubMed ID

  • 22243740

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2011.12.016

Language

  • eng

Conference Location

  • United States