Regulated shuttling of the histone deacetylase HDAC5 to the nucleus may put a brake on cocaine addiction.

Journal Article

The histone deacetylase HDAC5 has been shown to regulate behavioral adaptations to cocaine. In this issue of Neuron, Taniguchi et al. (2012) describe a cAMP-dependent signaling pathway that regulates nuclear accumulation of HDAC5, suggesting a mechanism to couple cocaine with changes in HDAC5 function.

Full Text

Duke Authors

Cited Authors

  • West, AE

Published Date

  • January 12, 2012

Published In

Volume / Issue

  • 73 / 1

Start / End Page

  • 1 - 3

PubMed ID

  • 22243740

Pubmed Central ID

  • 22243740

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2011.12.016


  • eng

Conference Location

  • United States