Biological functions and transcriptional targets of CaRF in neurons.

Journal Article (Journal Article;Review)

Calcium-response factor (CaRF) is a unique DNA-binding protein first recognized as a transcription factor for its role in modulating transcription of the gene encoding Brain-Derived Neurotrophic Factor (BDNF) in neurons. Here I review evidence for the biological functions and transcriptional targets of CaRF in the brain and discuss potential mechanisms by which calcium-activated signaling pathways may modulate CaRF-dependent transcription. These data paint an emerging picture of CaRF as a regulatory nexus for signaling pathways that control aspects of synaptic development and neuronal function.

Full Text

Duke Authors

Cited Authors

  • West, AE

Published Date

  • May 2011

Published In

Volume / Issue

  • 49 / 5

Start / End Page

  • 290 - 295

PubMed ID

  • 21565403

Pubmed Central ID

  • PMC3114298

Electronic International Standard Serial Number (EISSN)

  • 1532-1991

Digital Object Identifier (DOI)

  • 10.1016/j.ceca.2011.04.003


  • eng

Conference Location

  • Netherlands