Biological functions and transcriptional targets of CaRF in neurons.
Journal Article (Journal Article;Review)
Calcium-response factor (CaRF) is a unique DNA-binding protein first recognized as a transcription factor for its role in modulating transcription of the gene encoding Brain-Derived Neurotrophic Factor (BDNF) in neurons. Here I review evidence for the biological functions and transcriptional targets of CaRF in the brain and discuss potential mechanisms by which calcium-activated signaling pathways may modulate CaRF-dependent transcription. These data paint an emerging picture of CaRF as a regulatory nexus for signaling pathways that control aspects of synaptic development and neuronal function.
Full Text
Duke Authors
Cited Authors
- West, AE
Published Date
- May 2011
Published In
Volume / Issue
- 49 / 5
Start / End Page
- 290 - 295
PubMed ID
- 21565403
Pubmed Central ID
- PMC3114298
Electronic International Standard Serial Number (EISSN)
- 1532-1991
Digital Object Identifier (DOI)
- 10.1016/j.ceca.2011.04.003
Language
- eng
Conference Location
- Netherlands