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Blood pressure and heart rate effects, weight loss and maintenance during long-term phentermine pharmacotherapy for obesity.

Publication ,  Journal Article
Hendricks, EJ; Greenway, FL; Westman, EC; Gupta, AK
Published in: Obesity (Silver Spring)
December 2011

There is a perception that phentermine pharmacotherapy for obesity increases blood pressure and heart rate (HR), exposing treated patients to increased cardiovascular risk. We collected data from phentermine-treated (PT) and phentermine-untreated (P0) patients at a private weight management practice, to examine blood pressure, HR, and weight changes. Records of 300 sequential returning patients were selected who had been treated with a low-carbohydrate ketogenic diet if their records included complete weight, blood pressure, and HR data from seven office examinations during the first 12 weeks of therapy. The mean time in therapy, time range, and mode was 92 (97.0), 12-624, and 52 weeks. 14% were normotensive, 52% were prehypertensive, and 34% were hypertensive at their first visit or had a previous diagnosis of hypertension. PT subjects systolic blood pressure/diastolic blood pressure (SBP/DBP) declined from baseline at all data points (SBP/DBP -6.9/-5.0 mm Hg at 26, and -7.3/-5.4 at 52 weeks). P0 subjects' declines of SBP/DBP at both 26 and 52 weeks were -8.9/-6.3 but the difference from the treated cohort was not significant. HR changes in treated/untreated subjects at weeks 26 (-0.9/-3.5) and 52 (+1.2/-3.6) were not significant. Weight loss was significantly greater in the PT cohort for week 1 through 104 (P = 0.0144). These data suggest phentermine treatment for obesity does not result in increased SBP, DBP, or HR, and that weight loss assisted with phentermine treatment is associated with favorable shifts in categorical blood pressure and retardation of progression to hypertension in obese patients.

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Published In

Obesity (Silver Spring)

DOI

EISSN

1930-739X

Publication Date

December 2011

Volume

19

Issue

12

Start / End Page

2351 / 2360

Location

United States

Related Subject Headings

  • Weight Loss
  • Reference Values
  • Phentermine
  • Obesity
  • Middle Aged
  • Male
  • Hypertension
  • Humans
  • Heart Rate
  • Female
 

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Hendricks, E. J., Greenway, F. L., Westman, E. C., & Gupta, A. K. (2011). Blood pressure and heart rate effects, weight loss and maintenance during long-term phentermine pharmacotherapy for obesity. Obesity (Silver Spring), 19(12), 2351–2360. https://doi.org/10.1038/oby.2011.94
Hendricks, Ed J., Frank L. Greenway, Eric C. Westman, and Alok K. Gupta. “Blood pressure and heart rate effects, weight loss and maintenance during long-term phentermine pharmacotherapy for obesity.Obesity (Silver Spring) 19, no. 12 (December 2011): 2351–60. https://doi.org/10.1038/oby.2011.94.
Hendricks EJ, Greenway FL, Westman EC, Gupta AK. Blood pressure and heart rate effects, weight loss and maintenance during long-term phentermine pharmacotherapy for obesity. Obesity (Silver Spring). 2011 Dec;19(12):2351–60.
Hendricks, Ed J., et al. “Blood pressure and heart rate effects, weight loss and maintenance during long-term phentermine pharmacotherapy for obesity.Obesity (Silver Spring), vol. 19, no. 12, Dec. 2011, pp. 2351–60. Pubmed, doi:10.1038/oby.2011.94.
Hendricks EJ, Greenway FL, Westman EC, Gupta AK. Blood pressure and heart rate effects, weight loss and maintenance during long-term phentermine pharmacotherapy for obesity. Obesity (Silver Spring). 2011 Dec;19(12):2351–2360.
Journal cover image

Published In

Obesity (Silver Spring)

DOI

EISSN

1930-739X

Publication Date

December 2011

Volume

19

Issue

12

Start / End Page

2351 / 2360

Location

United States

Related Subject Headings

  • Weight Loss
  • Reference Values
  • Phentermine
  • Obesity
  • Middle Aged
  • Male
  • Hypertension
  • Humans
  • Heart Rate
  • Female