Bacterial vaginosis as a risk factor for high-grade cervical lesions and cancer in HIV-seropositive women.


Journal Article

To assess the effect of bacterial vaginosis (BV) on the risk of high-grade squamous intraepithelial lesions (HSIL) among HIV-seropositive women.A hospital-based prospective cohort study of HIV-seropositive women was conducted in Johannesburg, South Africa from January 2005 to September 2009. Multivariate log-binomial and Poisson regressions were used to estimate prevalence and rate ratios, respectively.Among 1954 HIV-seropositive women, the baseline prevalence of HSIL was 17%. BV prevalence was high (54%) and showed no association with prevalence of HSIL (adjusted prevalence ratio, 1.12; 95% confidence intervals (CI), 0.92-1.35) nor with cervical lesion progression at follow-up visit (n=503) (adjusted rate ratio: 1.00; 95% CI, 0.65-1.53).Among HIV-seropositive women, BV was not associated with an increased risk of HSIL or cervical lesion progression.

Full Text

Cited Authors

  • Denslow, SA; Westreich, DJ; Firnhaber, C; Michelow, P; Williams, S; Smith, JS

Published Date

  • September 2011

Published In

Volume / Issue

  • 114 / 3

Start / End Page

  • 273 - 277

PubMed ID

  • 21683359

Pubmed Central ID

  • 21683359

Electronic International Standard Serial Number (EISSN)

  • 1879-3479

International Standard Serial Number (ISSN)

  • 0020-7292

Digital Object Identifier (DOI)

  • 10.1016/j.ijgo.2011.03.011


  • eng