Bacterial vaginosis as a risk factor for high-grade cervical lesions and cancer in HIV-seropositive women.
To assess the effect of bacterial vaginosis (BV) on the risk of high-grade squamous intraepithelial lesions (HSIL) among HIV-seropositive women.A hospital-based prospective cohort study of HIV-seropositive women was conducted in Johannesburg, South Africa from January 2005 to September 2009. Multivariate log-binomial and Poisson regressions were used to estimate prevalence and rate ratios, respectively.Among 1954 HIV-seropositive women, the baseline prevalence of HSIL was 17%. BV prevalence was high (54%) and showed no association with prevalence of HSIL (adjusted prevalence ratio, 1.12; 95% confidence intervals (CI), 0.92-1.35) nor with cervical lesion progression at follow-up visit (n=503) (adjusted rate ratio: 1.00; 95% CI, 0.65-1.53).Among HIV-seropositive women, BV was not associated with an increased risk of HSIL or cervical lesion progression.
Denslow, SA; Westreich, DJ; Firnhaber, C; Michelow, P; Williams, S; Smith, JS
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