Retrospective postmortem dementia assessment. Validation of a new clinical interview to assist neuropathologic study.

Journal Article (Journal Article)

Neuropathologic studies of dementia and normal aging suffer from a lack of individuals examined for the presence and severity of dementia before death. To increase clinical information in such cases, a retrospective collateral interview was developed. Thirty-nine individuals were studied; 27 had autopsies. In all cases, the autopsy confirmed the Retrospective Collateral Dementia Interview (RCDI) diagnosis of the presence or absence of dementia; the RCDI had a sensitivity of 88% and a specificity of 80% for specifically detecting probable Alzheimer's disease. Agreement between the RCDI and premortem diagnosis was 96%; between RCDI and medical records, 100%. Agreement between RCDI staging of dementia severity and the last assessment of the living subject was 70%; between the RCDI and a brief staging at death, 86%. This validation confirms the value of postmortem interviews with close informants to assess dementia presence and severity.

Full Text

Duke Authors

Cited Authors

  • Davis, PB; White, H; Price, JL; McKeel, D; Robins, LN

Published Date

  • June 1991

Published In

Volume / Issue

  • 48 / 6

Start / End Page

  • 613 - 617

PubMed ID

  • 2039384

International Standard Serial Number (ISSN)

  • 0003-9942

Digital Object Identifier (DOI)

  • 10.1001/archneur.1991.00530180069019


  • eng

Conference Location

  • United States