The development and testing of aptamers for cancer.

Journal Article (Review)

Aptamers are single-stranded DNA or RNA oligonucleotides that have specific three-dimensional structures and bind to target molecules. Several unique properties of aptamers, including high binding specificity, low immunogenicity, structural stability and ease of synthesis, have made aptamers promising agents for directed therapy against cancer targets. Aptamers with anti-neoplastic activity against extracellular, cell membrane and intracellular targets have been developed. Aptamers also have been incorporated into novel constructs as tools for delivering therapeutic agents. This review discusses the most recent advances in the application of aptamer technology for cancer therapy.

Duke Authors

Cited Authors

  • Barbas, AS; White, RR

Published Date

  • June 2009

Published In

Volume / Issue

  • 10 / 6

Start / End Page

  • 572 - 578

PubMed ID

  • 19513946

Electronic International Standard Serial Number (EISSN)

  • 2040-3429

International Standard Serial Number (ISSN)

  • 1472-4472

Language

  • eng