Genetic and environmental influences on forced expiratory volume in midlife: a cross-cultural replication.


Journal Article

Previous research has shown that forced expiratory volume (FEV) is a useful predictor of remaining life in older adults. The present analyses are an attempt to replicate results from a study of Swedish twins which demonstrated substantial heritability of FEV with a sample of middle-aged Russian adult twins. Data were collected from 116 pairs of Russian twins (monozygote = 71, dizygotic = 45, mean age = 40.9 years). Phenotypic correlations between FEV, age, gender, height, and cigarette consumption (in pack years) were all significant, ranging from -.72 to .31. After the effects of age, gender, height, and smoking were partialled out of FEV, quantitative genetic analyses were conducted. Shared environmental effects were significant, accounting for 47% of the variance in FEV. Genetic effects, which accounted for about 28% of the variance, could be dropped from the model without a significant decrease in the fit. These results are discussed in relation to previous research conducted in other countries.

Full Text

Cited Authors

  • Whitfield, KE; Grant, J; Ravich-Scherbo, I; Marytuina, T; Iboutolina, A

Published Date

  • July 1999

Published In

Volume / Issue

  • 25 / 3

Start / End Page

  • 255 - 265

PubMed ID

  • 10467515

Pubmed Central ID

  • 10467515

Electronic International Standard Serial Number (EISSN)

  • 1096-4657

International Standard Serial Number (ISSN)

  • 0361-073X

Digital Object Identifier (DOI)

  • 10.1080/036107399244020


  • eng