Rhodium-catalyzed asymmetric cyclization/hydroboration of 1,6-enynes.
Published
Journal Article
[reaction: see text] Reaction of enyne 1 with catecholborane catalyzed by a 1:1 mixture of [Rh(COD)(2)](+)SbF(6)(-) and (S)-BINAP (5 mol %) followed by Pd-catalyzed arylation with p-IC(6)H(4)CF(3) gave benzylidenecyclopentane 5 in 65% yield with 88% ee. Rhodium-catalyzed asymmetric cyclization/hydroboration followed either by Pd-catalyzed arylation or by oxidation was applied to the synthesis of a number of chiral, nonracemic carbocycles and heterocycles.
Full Text
Duke Authors
Cited Authors
- Kinder, RE; Widenhoefer, RA
Published Date
- May 2006
Published In
Volume / Issue
- 8 / 10
Start / End Page
- 1967 - 1969
PubMed ID
- 16671758
Pubmed Central ID
- 16671758
Electronic International Standard Serial Number (EISSN)
- 1523-7052
International Standard Serial Number (ISSN)
- 1523-7052
Digital Object Identifier (DOI)
- 10.1021/ol052986t
Language
- eng