Antibacterial activity of fullerene water suspensions (nC60) is not due to ROS-mediated damage.


Journal Article

The cytotoxic and antibacterial properties of nC 60, a buckminsterfullerene water suspension, have been attributed to photocatalytically generated reactive oxygen species (ROS). However, in this work, neither ROS production nor ROS-mediated damage is found in nC 60-exposed bacteria. Furthermore, the colorimetric methods used to evaluate ROS production and damage are confounded by interactions between nC 60 and the reagents, yielding false positives. Instead, we propose that nC 60 exerts ROS-independent oxidative stress, thus reconciling conflicting results in the literature.

Full Text

Duke Authors

Cited Authors

  • Lyon, DY; Brunet, L; Hinkal, GW; Wiesner, MR; Alvarez, PJJ

Published Date

  • May 2008

Published In

Volume / Issue

  • 8 / 5

Start / End Page

  • 1539 - 1543

PubMed ID

  • 18410152

Pubmed Central ID

  • 18410152

Electronic International Standard Serial Number (EISSN)

  • 1530-6992

International Standard Serial Number (ISSN)

  • 1530-6984

Digital Object Identifier (DOI)

  • 10.1021/nl0726398


  • eng