Gold nanocages as contrast agents for spectroscopic optical coherence tomography

Journal Article

We describe gold nanocages as a new class of potential contrast agent for spectroscopic optical coherence tomography (OCT). Monodispersed gold nanocages of an ∼35 nm edge length exhibit strong optical resonance, with the peak wavelength tunable in the near-infrared range. We characterized the optical properties of the nanocage by using OCT experiments along with numerical calculations, revealing an absorption cross section approximately 5 orders of magnitude larger than conventional dyes. Experiments with tissue phantoms demonstrated that the nanocages provide enhanced contrast for spectroscopic as well as conventional intensity-based OCT imaging. © 2005 Optical Society of America.

Full Text

Duke Authors

Cited Authors

  • Cang, H; Sun, T; Li, Z-Y; Chen, J; Wiley, BJ; Xia, Y; Li, X

Published Date

  • 2005

Published In

Volume / Issue

  • 30 / 22

Start / End Page

  • 3048 - 3050

PubMed ID

  • 16315717

International Standard Serial Number (ISSN)

  • 0146-9592

Digital Object Identifier (DOI)

  • 10.1364/OL.30.003048