Failure to adhere to protocol specified radiation therapy guidelines was associated with decreased survival in RTOG 9704--a phase III trial of adjuvant chemotherapy and chemoradiotherapy for patients with resected adenocarcinoma of the pancreas.


Journal Article

In Radiation Therapy Oncology Group 9704, as previously published, patients with resected pancreatic adenocarcinoma received continuous infusion 5-FU and concurrent radiotherapy (5FU-RT). 5FU-RT treatment was preceded and followed by randomly assigned chemotherapy, either 5-FU or gemcitabine. This analysis explored whether failure to adhere to specified RT guidelines influenced survival and/or toxicity.RT requirements were protocol specified. Adherence was scored as per protocol (PP) or less than per protocol (

Full Text

Duke Authors

Cited Authors

  • Abrams, RA; Winter, KA; Regine, WF; Safran, H; Hoffman, JP; Lustig, R; Konski, AA; Benson, AB; Macdonald, JS; Rich, TA; Willett, CG

Published Date

  • February 2012

Published In

Volume / Issue

  • 82 / 2

Start / End Page

  • 809 - 816

PubMed ID

  • 21277694

Pubmed Central ID

  • 21277694

Electronic International Standard Serial Number (EISSN)

  • 1879-355X

International Standard Serial Number (ISSN)

  • 0360-3016

Digital Object Identifier (DOI)

  • 10.1016/j.ijrobp.2010.11.039


  • eng