Failure to adhere to protocol specified radiation therapy guidelines was associated with decreased survival in RTOG 9704--a phase III trial of adjuvant chemotherapy and chemoradiotherapy for patients with resected adenocarcinoma of the pancreas.

Published

Journal Article

PURPOSE: In Radiation Therapy Oncology Group 9704, as previously published, patients with resected pancreatic adenocarcinoma received continuous infusion 5-FU and concurrent radiotherapy (5FU-RT). 5FU-RT treatment was preceded and followed by randomly assigned chemotherapy, either 5-FU or gemcitabine. This analysis explored whether failure to adhere to specified RT guidelines influenced survival and/or toxicity. METHODS AND MATERIALS: RT requirements were protocol specified. Adherence was scored as per protocol (PP) or less than per protocol (

Full Text

Duke Authors

Cited Authors

  • Abrams, RA; Winter, KA; Regine, WF; Safran, H; Hoffman, JP; Lustig, R; Konski, AA; Benson, AB; Macdonald, JS; Rich, TA; Willett, CG

Published Date

  • February 1, 2012

Published In

Volume / Issue

  • 82 / 2

Start / End Page

  • 809 - 816

PubMed ID

  • 21277694

Pubmed Central ID

  • 21277694

Electronic International Standard Serial Number (EISSN)

  • 1879-355X

Digital Object Identifier (DOI)

  • 10.1016/j.ijrobp.2010.11.039

Language

  • eng

Conference Location

  • United States