Outcomes in a series of 103 retroperitoneal sarcomas.

Journal Article (Journal Article)

AIMS: To report the effect on outcome of selection in patients receiving intra-operative electron beam radiation (IOERT) and external beam radiation therapy (EBRT). METHODS: One hundred and three patients treated for primary RS were studied. Median follow-up was 27 months. Clinical presentation, tumor characteristics, and treatment methods were analyzed to determine impact on survival and recurrence and if selection was occurring. RESULTS: Mean age was 55+/-17 years. Mean tumor size was 15+/-6cm and 88 were high-grade. Complete gross tumor resection (CR) occurred in 62 patients and improved survival vs. both debulking (p=0.0005) and biopsy (p<0.0001). The 5- and 10-year survival rates were 62% and 52% for those with CR vs. 29% and 20% after incomplete resection. Among the 62 CR patients, there was selection to receive additional EBRT+/-IOERT in patients with high-grade tumors (p=0.005) and/or microscopically positive margins (p=0.011). In these high-risk patients there was a trend for IOERT to further augment survival vs. EBRT alone and to increase the time to both local and distant recurrences (p=0.036). CONCLUSIONS: Complete gross resection is the primary form of curative treatment for retroperitoneal sarcomas. Selection led to patients with high-risk tumors receiving additional radiation therapy. There appears to be a beneficial effect of IOERT plus EBRT in these high-risk patients after complete tumor resection.

Full Text

Duke Authors

Cited Authors

  • Pierie, J-PEN; Betensky, RA; Choudry, U; Willett, CG; Souba, WW; Ott, MJ

Published Date

  • December 2006

Published In

Volume / Issue

  • 32 / 10

Start / End Page

  • 1235 - 1241

PubMed ID

  • 16919908

International Standard Serial Number (ISSN)

  • 0748-7983

Digital Object Identifier (DOI)

  • 10.1016/j.ejso.2006.07.002


  • eng

Conference Location

  • England